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Table 2 Automatic Interactive Optimizer (AIO) and clinical plan results

From: Automatic interactive optimization for volumetric modulated arc therapy planning

 

Plan

Clinical

Nominal AIO

AIO OLD = 25 ††

AIO OLD = 75 ††

AIO 3 objectives/OAR ||

AIO 6 objectives/OAR ||

AIO T = 7.5s

AIO T = 30s

 

PTVB V95 * (%)

99.1 ± 0.2

98.9 ± 0.5

99.5 ± 0.2

97.5 ± 1.2

99.2 ± 0.5

98.9 ± 0.5

98.7 ± 0.6

98.5 ± 0.9

 

PTVB V107 * (%)

1.1 ± 1.4

1.2 ± 1.6

0.5 ± 0.6

3.4 ± 3.6

0.5 ± 0.7

1.1 ± 1.2

1.9 ± 1.9

1.6 ± 1.6

 

PTVE V95 * (%)

98.2 ± 1.1

97.7 ± 0.7

98.7 ± 0.6

96.0 ± 1.6

98.3 ± 1.0

97.8 ± 1.0

97.4 ± 1.0

97.3 ± 1.0

 

PTVE V107 * (%)

14.5 ± 3.8

13.0 ± 5.4

9.5 ± 4.6

16.5 ± 6.2

10.3 ± 4.7

12.2 ± 5.0

13.7 ± 5.6

13.6 ± 5.1

Max dose (Gy)

Spinal Cord

39.0 ± 3.7

39.1 ± 4.1

38.3 ± 4.0

39.8 ± 3.7

38.5 ± 4.2

38.8 ± 4.0

39.0 ± 3.8

38.3 ± 4.9

Brainstem

37.7 ± 7.7

37.3 ± 8.0

37.7 ± 8.3

38.8 ± 7.8

37.0 ± 7.2

37.6 ± 8.3

37.0 ± 7.9

37.5 ± 8.3

Mean dose (Gy)

Contralateral Parotid

19.6 ± 5.6

18.7 ± 5.7

21.4 ± 6.9

17.6 ± 5.3

21.4 ± 6.7

19.5 ± 6.0

18.5 ± 5.5

19.0 ± 5.9

Ipisilateral Parotid

31.2 ± 8.1

29.9 ± 8.4

32.0 ± 8.5

27.5 ± 7.1

32.1 ± 8.7

30.5 ± 8.3

29.5 ± 7.9

29.8 ± 8.1

Contralateral Submandibular

31.2 ± 7.4

29.6 ± 8.0

34.0 ± 8.6

27.7 ± 7.3

33.9 ± 8.6

30.6 ± 8.3

29.4 ± 7.0

30.5 ± 7.4

Oral Cavity

28.6 ± 7.0

24.7 ± 7.9

26.7 ± 8.7

23.6 ± 7.6

27.0 ± 10.3

25.6 ± 8.3

24.2 ± 6.9

26.1 ± 7.4

Comp sal †

26.2 ± 5.5

25.0 ± 5.8

27.7 ± 6.5

24.2 ± 5.3

27.8 ± 6.2

25.8 ± 5.9

24.7 ± 5.4

25.2 ± 5.7

Comp swal †

28.7 ± 8.0

23.1 ± 8.7

27.0 ± 9.5

21.7 ± 8.7

26.7 ± 9.5

23.8 ± 9.2

22.5 ± 8.8

23.4 ± 8.7

  1. AIO and clinical plan results averaged over all 10 patients using different AIO settings. Clinically acceptable doses to the brainstem and spinal cord were achieved in all plans.
  2. Abbreviations:
  3. *PTVB, PTVE, PTVT: Boost, elective, transition planning target volumes, respectively.
  4. †Compsal / Compswal: Composite salivary glands / Composite swallowing muscles.
  5. ††AIO OLD = 25/75: AIO plan using an objective-line distance (OLD) of 25/75 pixels, a pause time of 15 seconds and 9 objectives per OAR.
  6. ||AIO 3/6 objectives per OAR: AIO plan using 3/6 objectives per OAR, a pause time of 15 seconds and an OLD of 50 pixels.
  7. AIO T = 7.5/30s: AIO plan using pause times (T) of 7.5/30 seconds, 9 objectives per OAR and an OLD of 50 pixels.
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Radiation Oncology

ISSN: 1748-717X

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