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Table 2 Automatic Interactive Optimizer (AIO) and clinical plan results

From: Automatic interactive optimization for volumetric modulated arc therapy planning

  Plan Clinical Nominal AIO AIO OLD = 25 †† AIO OLD = 75 †† AIO 3 objectives/OAR || AIO 6 objectives/OAR || AIO T = 7.5s AIO T = 30s
  PTVB V95 * (%) 99.1 ± 0.2 98.9 ± 0.5 99.5 ± 0.2 97.5 ± 1.2 99.2 ± 0.5 98.9 ± 0.5 98.7 ± 0.6 98.5 ± 0.9
  PTVB V107 * (%) 1.1 ± 1.4 1.2 ± 1.6 0.5 ± 0.6 3.4 ± 3.6 0.5 ± 0.7 1.1 ± 1.2 1.9 ± 1.9 1.6 ± 1.6
  PTVE V95 * (%) 98.2 ± 1.1 97.7 ± 0.7 98.7 ± 0.6 96.0 ± 1.6 98.3 ± 1.0 97.8 ± 1.0 97.4 ± 1.0 97.3 ± 1.0
  PTVE V107 * (%) 14.5 ± 3.8 13.0 ± 5.4 9.5 ± 4.6 16.5 ± 6.2 10.3 ± 4.7 12.2 ± 5.0 13.7 ± 5.6 13.6 ± 5.1
Max dose (Gy) Spinal Cord 39.0 ± 3.7 39.1 ± 4.1 38.3 ± 4.0 39.8 ± 3.7 38.5 ± 4.2 38.8 ± 4.0 39.0 ± 3.8 38.3 ± 4.9
Brainstem 37.7 ± 7.7 37.3 ± 8.0 37.7 ± 8.3 38.8 ± 7.8 37.0 ± 7.2 37.6 ± 8.3 37.0 ± 7.9 37.5 ± 8.3
Mean dose (Gy) Contralateral Parotid 19.6 ± 5.6 18.7 ± 5.7 21.4 ± 6.9 17.6 ± 5.3 21.4 ± 6.7 19.5 ± 6.0 18.5 ± 5.5 19.0 ± 5.9
Ipisilateral Parotid 31.2 ± 8.1 29.9 ± 8.4 32.0 ± 8.5 27.5 ± 7.1 32.1 ± 8.7 30.5 ± 8.3 29.5 ± 7.9 29.8 ± 8.1
Contralateral Submandibular 31.2 ± 7.4 29.6 ± 8.0 34.0 ± 8.6 27.7 ± 7.3 33.9 ± 8.6 30.6 ± 8.3 29.4 ± 7.0 30.5 ± 7.4
Oral Cavity 28.6 ± 7.0 24.7 ± 7.9 26.7 ± 8.7 23.6 ± 7.6 27.0 ± 10.3 25.6 ± 8.3 24.2 ± 6.9 26.1 ± 7.4
Comp sal 26.2 ± 5.5 25.0 ± 5.8 27.7 ± 6.5 24.2 ± 5.3 27.8 ± 6.2 25.8 ± 5.9 24.7 ± 5.4 25.2 ± 5.7
Comp swal 28.7 ± 8.0 23.1 ± 8.7 27.0 ± 9.5 21.7 ± 8.7 26.7 ± 9.5 23.8 ± 9.2 22.5 ± 8.8 23.4 ± 8.7
  1. AIO and clinical plan results averaged over all 10 patients using different AIO settings. Clinically acceptable doses to the brainstem and spinal cord were achieved in all plans.
  2. Abbreviations:
  3. *PTVB, PTVE, PTVT: Boost, elective, transition planning target volumes, respectively.
  4. Compsal / Compswal: Composite salivary glands / Composite swallowing muscles.
  5. ††AIO OLD = 25/75: AIO plan using an objective-line distance (OLD) of 25/75 pixels, a pause time of 15 seconds and 9 objectives per OAR.
  6. ||AIO 3/6 objectives per OAR: AIO plan using 3/6 objectives per OAR, a pause time of 15 seconds and an OLD of 50 pixels.
  7. AIO T = 7.5/30s: AIO plan using pause times (T) of 7.5/30 seconds, 9 objectives per OAR and an OLD of 50 pixels.