Table 2 Incidence and relative risk (RR) of specific late toxicity
Late toxicities | No. of studies | No. of severe late toxicity/total no. of patients | Incidence of severe late toxicity, % (95% CI) | RR | ||
|---|---|---|---|---|---|---|
Chemoradiotherapy | Radiotherapy | Chemoradiotherapy | Radiotherapy | |||
Overall late toxicities | 5 | 150/547 | 118/555 | 30.7(18-47.2) | 21.7(13.3-33.4) | 1.349(1.108-1.619) |
Ear (deafness/otitis) | 5 | 107/547 | 72/555 | 20.7(12-33.2) | 13.3(9.3-18.7) | 1.567(1.197-2.052) |
Cranial neuropathy | 4 | 19/431 | 21/441 | 5.5(3.6-8.5) | 5.2(3.4-7.9) | 0.923(0.351-2.427) |
Soft tissue damage at neck | 4 | 17/431 | 17/441 | 4.6(2.9-7.2) | 4.2(2.6-6.6) | 1.007(0.522-1.94) |
Peripheral neuropathy | 3 | 6/372 | 2/385 | 1.8(0.9-3.9) | 1.6(0.5-5) | 2.295(0.41-12.845) |
Temporal lobe necrosis | 2 | 5/200 | 11/209 | 2.9(1.3-6.5) | 5.8(3.2-10.2) | 0.47(0.079-2.809) |
Brachial plexopathy | 2 | 0/214 | 1/227 | 0.6(0.1-4.1) | 0.7(0.1-3.3) | 0.567(0.048-6.707) |
Endocrine dysfunction | 2 | 15/214 | 12/227 | 7.1(4.3-11.4) | 5.3(3.1-9.2) | 1.312(0.629-2.74) |
Visual toxicity | 2 | 3/200 | 3/209 | 2.4(0.8-7.2) | 2.1(0.7-6.4) | 1.14(0.236-5.507) |
Dysphagia | 2 | 2/214 | 0/227 | 1.2(0.3-3.9) | 0.5(0.1-3.6) | 2.973(0.272-32.51) |
Bone necrosis | 2 | 2/330 | 1/334 | 0.6(0.2-2.4) | 0.5(0.1-2.3) | 1.622(0.201-13.111) |
Mucosal damage | 2 | 4/231 | 1/232 | 2.1(0.8-5.1) | 0.7(0.1-3.2) | 2.891(0.431-19.409) |
Radiation-induced malignancy | 2 | 0/330 | 1/333 | 0.3(0-2.1) | 0.5(0.1-2.3) | 0.524(0.044-6.226) |