Concurrent chemoradiotherapy was associated with a higher severe late toxicity rate in nasopharyngeal carcinoma patients compared with radiotherapy alone: a meta-analysis based on randomized controlled trials

Du, Cheng-run; Ying, Hong-mei; Kong, Fang-fang; Zhai, Rui-ping; Hu, Chao-su

doi:10.1186/s13014-015-0377-9

Table 1 Characteristics of RCTs Included in the meta-analysis

From: Concurrent chemoradiotherapy was associated with a higher severe late toxicity rate in nasopharyngeal carcinoma patients compared with radiotherapy alone: a meta-analysis based on randomized controlled trials

Study	No. of patients	Inclusion period	Stage	Median follow-up (Ms)	Group	Radiotherapy	CCRT	AC
Lee et al. (2011) [19]	93	1999-2004	AJCC stage T3-4 N0-1 M0	75	CCRT + AC	≥66 Gy (2 Gy/Fx/d, 5Fx/wk)	Cisplatin 100 mg/m2 intravenously every 3 weeks	Cisplatin 80/m2 + fluorouracil 1000 mg/m2/day by 96-h infusion every 4 weeks for 3 cycles.
Lee et al. (2011) [19]	93	1999-2004	AJCC stage T3-4 N0-1 M0	75	RT	≥66 Gy (2 Gy/Fx/d, 5Fx/wk)	Cisplatin 100 mg/m2 intravenously every 3 weeks
Lee et al. (2010) [21]	348	1999–2004	AJCC stage III and IV, any T, N2 or N3, M0	71	CCRT + AC	≥66 Gy (2 Gy/Fx/d, 5Fx/wk)	Cisplatin 100 mg/m2 every 3wks on days 1,22,43	Cisplatin 80 mg/m2 + fluorouracil 1000 mg/m2/d every 4 wks on days 71,99 and 127
Lee et al. (2010) [21]	348	1999–2004	AJCC stage III and IV, any T, N2 or N3, M0	71	RT	≥66 Gy (2 Gy/Fx/d, 5Fx/wk)	Cisplatin 100 mg/m2 every 3wks on days 1,22,43
Chen et al. (2013) [18]	316	2002-2005	AJCC stage III and IVb	70	CCRT + AC	≥66 Gy (2 Gy/Fx/d, 5Fx/wk)	Cisplatin 40 mg/m2 on day 1 weekly	Cisplatin 80 mg/m2 on day 1 and fluorouracil 800 mg/m2 daily as an intravenous, 120-hour infusion) on days 1 through 5
Chen et al. (2013) [18]	316	2002-2005	AJCC stage III and IVb	70	RT	≥66 Gy (2 Gy/Fx/d, 5Fx/wk)	Cisplatin 40 mg/m2 on day 1 weekly
Chen et al. (2011) [20]	230	2003-2007	Chinese 1992 staging system stage II	60	CCRT	68–70 Gy (2Gy/Fx/d, 5Fx/wk)	Cisplatin 30 mg/m2 weekly	none
Chen et al. (2011) [20]	230	2003-2007	Chinese 1992 staging system stage II	60	RT	68–70 Gy (2Gy/Fx/d, 5Fx/wk)	Cisplatin 30 mg/m2 weekly	none
Wu et al. (2013) [17]	115	2001-2003	AJCC stage III and IVb	114	CCRT	70-74Gy (2Gy/Fx/d, 5Fx/wk)	Oxaliplatin70 mg/m2 on days 1 every week	none
Wu et al. (2013) [17]	115	2001-2003	AJCC stage III and IVb	114	RT	70-74Gy (2Gy/Fx/d, 5Fx/wk)	Oxaliplatin70 mg/m2 on days 1 every week	none

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