Table 1 Characteristics of patients with or without anastomotic leakage, treated with neo-adjuvant chemoradiation followed by transhiatal esophagectomy

Mean age

62.4 [41–77]

63.8 [41–82]

0.83

Gender:

 Male (n = 49)

13 (27%)

36 (73%)

 Female (n = 4)

0 (0%)

4 (100%)

0.56

BMI

27.5 [21–41]

26.4 [19–35]

0.65

Co-morbidity:

 0 (n = 13)

3 (23%)

10 (77%)

 1 (n = 18)

4 (22%)

14 (78%)

 2 or more (n = 22)

6 (27%)

16 (73%)

0.93

ASA classification:

 I (n = 8)

3 (38%)

5 (63%)

 II (n = 41)

9 (22%)

32 (78%)

 III (n = 4)

1 (25%)

3 (75%)

0.65

Histologic type:

 Adenocarcinoma (n = 49)

12 (24%)

37 (76%)

 Squamous cell carcinoma (n = 4)

1 (25%)

3 (75%)

0.98

Mean volume (cm³)

53.1 [33–71]

46.6 [21–92]

0.10

Mean dose (Gy)

26.4 [6–41]

31.6 [15–42]

0.16

V20

71.2%

88.3%

0.54

V25

53.8%

66.2%

0.27

V30

45.4%

57.3%

0.24

V35

39.1%

50.3%

0.24

V40

26.2%

36.5%

0.32

OR time (min)

172 [118–329]

187 [134–292]

0.09

Resection type:

 Open (n = 21)

7 (33%)

14 (67%)

 Laparoscopic (n = 32)

6 (19%)

26 (81%)

0.23

Method of anastomosis:

 End-to-end continuous (n = 33)

6 (18%)

27 (82%)

 End-to-end interrupted (n = 11)

4 (36%)

7 (64%)

 Side-to -side stapler (n = 9)

3 (33%)

6 (67%)

0.38

Interval last RT– surgery (days)

70 [40–127]

69 [31–121]

0.87

Hospital stay (days)

22 [13–71]

13 [6–35]

0.001