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Table 1 Summary of the dose differences calculated by the AAA and AXB algorithm with 2.5 and 1 mm CGS for the 6XFFF beam

From: Dose calculation of Acuros XB and Anisotropic Analytical Algorithm in lung stereotactic body radiotherapy treatment with flattening filter free beams and the potential role of calculation grid size

Structures Metrics Unit AAA 2.5mm AXB 2.5mm AAA 1mm AXB 1mm
PTV_lung Dmin Gy 44.0 ± 0.8 42.0 ± 1.3a 44.6 ± 0.6 42.2 ± 2.0b
Dmax Gy 57.2 ± 1.7 57.6 ± 1.7 58.5 ± 1.5 58.0 ± 2.0
Dmean Gy 51.9 ± 0.8 51.2 ± 1.2a 52.9 ± 0.8 51.6 ± 1.2b
PTV_soft Dmin Gy 46.9 ± 3.1 46.5 ± 3.3 46.6 ± 2.5 46.5 ± 3.0
Dmax Gy 57.2 ± 1.8 57.4 ± 2.1 58.1 ± 2.1 57.9 ± 1.9
Dmean Gy 53.1 ± 1.8 52.9 ± 1.7 52.9 ± 2.0 52.9 ± 1.7
Aorta Dmax Gy 12.9 ± 9.7 12.6 ± 9.8a 12.9 ± 9.6 12.4 ± 9.3b
Dmean Gy 2.6 ± 2.2 2.5 ± 2.1a 2.6 ± 2.2 2.5 ± 2.1b
Bronchial tree Dmax Gy 14.3 ± 10.4 14.4 ± 10.6 14.4 ± 10.4 14.4 ± 10.6
Dmean Gy 3.5 ± 2.5 3.5 ± 2.5 3.6 ± 2.6 3.5 ± 2.5
Chest wall V45 % 1.2 ± 1.9 1.1 ± 1.7 1.3 ± 1.9 1.2 ± 1.8b
V30 % 7.3 ± 8.9 7.0 ± 8.4 7.4 ± 8.9 7.0 ± 8.4b
V20 % 36.3 ± 31.2 34.1 ± 29.9a 37.2 ± 31.3 34.8 ± 30.1
Dmean Gy 5.5 ± 2.4 5.4 ± 2.4a 5.5 ± 2.4 5.4 ± 2.4b
Spinal cord Dmax Gy 8.0 ± 2.9 7.5 ± 2.7a 8.2 ± 2.9 7.7 ± 2.8b
Dmean Gy 1.5 ± 0.5 1.4 ± 0.4a 1.5 ± 0.5 1.4 ± 0.4b
Esophagus Dmax Gy 9.2 ± 3.4 8.9 ± 3.4a 9.3 ± 3.4 8.9 ± 3.4b
Dmean Gy 2.0 ± 0.7 1.9 ± 0.7a 2.0 ± 0.7 1.9 ± 0.7b
Heart Dmax Gy 18.1 ± 10.5 17.8 ± 10.6 18.2 ± 10.4 18.0 ± 10.5
Dmean Gy 1.4 ± 1.2 1.4 ± 1.2 1.4 ± 1.2 1.4 ± 1.2
Ipsilateral lung V5 % 24.5 ± 7.9 25.1 ± 8.0a 24.4 ± 7.8 25.0 ± 8.0b
V10 % 17.0 ± 7.6 17.1 ± 7.7 17.1 ± 7.6 17.1 ± 7.6
V20 % 7.7 ± 4.7 7.6 ± 4.2 7.7 ± 4.2 7.6 ± 4.2
Dmean Gy 5.0 ± 1.9 5.0 ± 2.0 5.0 ± 2.0 5.0 ± 2.0
Contralateral lung V5 % 0.6 ± 0.9 0.6 ± 0.9 0.7 ± 0.9 0.6 ± 0.9b
Dmean Gy 0.9 ± 0.4 0.9 ± 0.3 0.9 ± 0.4 0.9 ± 0.3
  1. Abbreviations: PTV_lung = PTV with a density in the lung range; PTV_soft = PTV with a density in the soft-tissue range; Dmin = minimum dose; Dmax = maximum dose; Dmean = mean dose; Vx was the volume of the organ receiving a dose of x or more; aWilcoxon signed-rank tests with p value <0.05 between AXB and AAA plan with 2.5 mm CGS; bWilcoxon signed-rank tests with p value <0.05 between AXB and AAA plan with 1 mm CGS.