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Table 2 NCI Common toxicity criteria (CTC) scale, version 3.0 of diarrhoea

From: Acute small-bowel toxicity during neoadjuvant combined radiochemotherapy in locally advanced rectal cancer: determination of optimal dose-volume cut-off value predicting grade 2–3 diarrhoea

Diarrhoea grade 1

Grade 2

Grade 3

Grade 4

Grade 5

Increase of <4 stools per day over baseline; mild increase in ostomy output

Increase of 4 – 6 stools per day over baseline; IV fluids indicated <24 hours; moderate increase in ostomy output compared to baseline; not interfering with ADL*

Increase of ≥7 stools per day over baseline; incontinence; IV fluids ≥24 hours; hospitalization; severe increase in ostomy output compared to baseline; interfering with ADL

Life-threatening consequences (e.g. hemodynamic collapse)

Death

Compared to baseline

  1. *Activities of Daily Living.