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Figure 3 | Radiation Oncology

Figure 3

From: Perilesional edema in radiation necrosis reflects axonal degeneration

Figure 3

IHC identifies the presence of both axonal and myelin abnormalities in the contralateral white matter. IHC for SMI-31 (a marker of healthy axons) and myelin basic protein (MBP) is presented at 10x and 20x magnification for the contralateral white matter of a representative mouse at week one (top row) and week 12 (bottom row) post-irradiation (PIR). The intensity of both markers is reduced, as well as the width of the white matter, at week 12 PIR in comparison to week one PIR. SMI-31 also appears to be affected more than MBP.

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