Table 2 Toxicity profiles according to oxaliplatin dose levels
|  | Level 1 (n = 3) |  | Level 2 (n = 3) |  | Level 3 (n = 6) |  |
|---|---|---|---|---|---|---|
NCI-CTCAE, version 3 | G1/2 | G3/4 | G1/2 | G3/4 | G1/2 | G3/4 |
Leukopenia | 0/2 | 0/0 | 1/0 | 0/0 | 1/3 | 1/0 |
Neutropenia | 0/1 | 0/0 | 0/0 | 0/0 | 0/2 | 1/0 |
Anemia | 1/0 | 0/0 | 2/0 | 0/0 | 4/0 | 0/0 |
Thrombocytopenia | 3/0 | 0/0 | 1/0 | 0/0 | 2/1 | 0/0 |
AST abnormalities | 3/0 | 0/0 | 1/0 | 0/0 | 2/0 | 0/0 |
ALT abnormalities | 2/1 | 0/0 | 1/0 | 0/0 | 3/0 | 0/0 |
Hyperbilirubinemia | 0/0 | 0/0 | 0/1 | 0/0 | 1/0 | 0/0 |
Anorexia | 0/0 | 0/0 | 1/2 | 0/0 | 1/0 | 0/0 |
Nausea | 0/0 | 0/0 | 0/1 | 0/0 | 1/0 | 0/0 |
Fatigue | 0/0 | 0/0 | 1/0 | 0/0 | 1/0 | 0/0 |
Alopecia | 0/0 | 0/0 | 1/0 | 0/0 | 0/0 | 0/0 |
Diarrhea | 2/0 | 0/0 | 1/1 | 0/0 | 3/0 | 0/0 |
Anorectal pain | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
Abdominal pain | 0/0 | 0/0 | 1/0 | 0/0 | 0/0 | 0/0 |
Vein inflammation | 0/0 | 0/0 | 0/2 | 0/0 | 0/0 | 0/0 |
Weight loss | 1/1 | 0/0 | 1/0 | 0/0 | 0/0 | 0/0 |
Radiation rash | 2/0 | 0/0 | 0/1 | 0/0 | 3/2 | 0/0 |
Sensory neuropathy | 0/0 | 0/0 | 0/0 | 0/0 | 1/0 | 0/0 |
Hand-foot syndrome | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |