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Table 2 Toxicity profiles according to oxaliplatin dose levels

From: A phase I dose escalation study of oxaliplatin plus oral S-1 and pelvic radiation in patients with locally advanced rectal cancer (SHOGUN trial)

  Level 1 (n = 3)   Level 2 (n = 3)   Level 3 (n = 6)  
NCI-CTCAE, version 3 G1/2 G3/4 G1/2 G3/4 G1/2 G3/4
Leukopenia 0/2 0/0 1/0 0/0 1/3 1/0
Neutropenia 0/1 0/0 0/0 0/0 0/2 1/0
Anemia 1/0 0/0 2/0 0/0 4/0 0/0
Thrombocytopenia 3/0 0/0 1/0 0/0 2/1 0/0
AST abnormalities 3/0 0/0 1/0 0/0 2/0 0/0
ALT abnormalities 2/1 0/0 1/0 0/0 3/0 0/0
Hyperbilirubinemia 0/0 0/0 0/1 0/0 1/0 0/0
Anorexia 0/0 0/0 1/2 0/0 1/0 0/0
Nausea 0/0 0/0 0/1 0/0 1/0 0/0
Fatigue 0/0 0/0 1/0 0/0 1/0 0/0
Alopecia 0/0 0/0 1/0 0/0 0/0 0/0
Diarrhea 2/0 0/0 1/1 0/0 3/0 0/0
Anorectal pain 0/0 0/0 0/0 0/0 0/0 0/0
Abdominal pain 0/0 0/0 1/0 0/0 0/0 0/0
Vein inflammation 0/0 0/0 0/2 0/0 0/0 0/0
Weight loss 1/1 0/0 1/0 0/0 0/0 0/0
Radiation rash 2/0 0/0 0/1 0/0 3/2 0/0
Sensory neuropathy 0/0 0/0 0/0 0/0 1/0 0/0
Hand-foot syndrome 0/0 0/0 0/0 0/0 0/0 0/0