|
All patients (n = 30)
|
RECIST responders (n = 5)
|
RECIST stable and progressive (n = 25)
|
Pre-ICT GTV >100 cc
3
(n = 21)
|
Pre-ICT GTV ≤100 cc
3
(n = 9)
|
---|
Variable
|
Pre-ICT
|
Post-ICT
|
P*
|
Pre-ICT
|
Post-ICT
|
P*
|
Pre-ICT
|
Post-ICT
|
P*
|
Pre-ICT
|
Post-ICT
|
P*
|
Pre-ICT
|
Post-ICT
|
P*
|
---|
GTV size, cm3
|
117
|
111
|
0.02
|
117
|
62
|
0.04
|
115
|
115
|
0.14
|
134
|
126
|
0.04
|
57
|
40
|
0.26
|
CTV size, cm3
|
344
|
297
|
0.03
|
350
|
218
|
0.04
|
338
|
338
|
0.22
|
372
|
379
|
0.03
|
193
|
160
|
0.86
|
PTV size, cm3
|
546
|
559
|
0.37
|
617
|
376
|
0.04
|
528
|
574
|
0.76
|
606
|
621
|
0.22
|
312
|
342
|
0.51
|
GTV95, %
|
100
|
100
|
0.73
|
100
|
100
|
0.32
|
100
|
100
|
0.99
|
100
|
100
|
0.74
|
100
|
100
|
0.32
|
CTV95, %
|
100
|
100
|
0.15
|
100
|
100
|
0.40
|
100
|
100
|
0.23
|
100
|
100
|
0.36
|
100
|
100
|
0.40
|
PTV95, %
|
96.7
|
96.1
|
0.31
|
98.6
|
99.1
|
0.89
|
96.5
|
94.8
|
0.26
|
96.5
|
95.0
|
0.43
|
97.0
|
97.3
|
0.37
|
Lung V5, %
|
50.5
|
51.8
|
0.31
|
50.0
|
51.2
|
0.14
|
50.5
|
52.6
|
0.68
|
52.5
|
52.2
|
0.20
|
50.0
|
51.2
|
0.95
|
Lung V20, %
|
29.1
|
28.9
|
0.24
|
29.3
|
26.3
|
0.04
|
28.9
|
29.6
|
0.86
|
29.5
|
29,6
|
0.61
|
27.9
|
27.9
|
0.11
|
Lung mean dose, Gy
|
18.1
|
18.5
|
0.45
|
18.2
|
16.4
|
0.04
|
18.1
|
18.6
|
0.68
|
18.2
|
18.5
|
0.96
|
16.1
|
18.6
|
0.11
|
Esophagus mean dose, Gy
|
28.2
|
28.4
|
0.24
|
26.7
|
24.0
|
0.89
|
28.7
|
28.4
|
0.20
|
31.4
|
32.3
|
0.42
|
22.2
|
22.2
|
0.44
|
Esophagus max, Gy
|
74.3
|
76.5
|
0.56
|
68.9
|
67.3
|
0.22
|
75.2
|
76.6
|
0.27
|
75.2
|
76.4
|
0.97
|
73.3
|
76.6
|
0.21
|
Esophagus V50, %
|
29.0
|
28.9
|
0.08
|
32.4
|
20.9
|
0.22
|
28.9
|
30.1
|
0.02
|
32.1
|
31.7
|
0.10
|
23.8
|
23.5
|
0.34
|
Heart mean dose, Gy
|
11.1
|
11.3
|
0.29
|
6.3
|
6.0
|
0.22
|
12.6
|
13.3
|
0.49
|
12.6
|
15.4
|
0.43
|
6.6
|
10.2
|
0.44
|
Heart V40, %
|
8.6
|
7.0
|
0.63
|
4.6
|
3.5
|
0.17
|
9.4
|
8.84
|
0.86
|
11.2
|
10.8
|
0.70
|
3.5
|
6.8
|
0.50
|
Spinal cord max, Gy
|
42.3
|
42.7
|
0.19
|
42.7
|
41.7
|
0.5
|
42.3
|
42.8
|
0.25
|
42.8
|
43.1
|
0.33
|
39.2
|
41.7
|
0.37
|
-
Abbreviations: GTV gross tumor volume, CTV clinical target volume, PTV planning target volume.
- *P values calculated with Wilcoxon matched-pairs signed-ranks test. Bolded p values are <0.05 and are taken as statistically significant.