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Table 3 Median values for dosimetric variables derived from scans obtained before and after induction chemotherapy

From: The impact of induction chemotherapy on the dosimetric parameters of subsequent radiotherapy: an investigation of 30 consecutive patients with locally-advanced non-small cell lung cancer and modern radiation planning techniques

  All patients (n = 30) RECIST responders (n = 5) RECIST stable and progressive (n = 25) Pre-ICT GTV >100 cc 3 (n = 21) Pre-ICT GTV ≤100 cc 3 (n = 9)
Variable Pre-ICT Post-ICT P* Pre-ICT Post-ICT P* Pre-ICT Post-ICT P* Pre-ICT Post-ICT P* Pre-ICT Post-ICT P*
GTV size, cm3 117 111 0.02 117 62 0.04 115 115 0.14 134 126 0.04 57 40 0.26
CTV size, cm3 344 297 0.03 350 218 0.04 338 338 0.22 372 379 0.03 193 160 0.86
PTV size, cm3 546 559 0.37 617 376 0.04 528 574 0.76 606 621 0.22 312 342 0.51
GTV95, % 100 100 0.73 100 100 0.32 100 100 0.99 100 100 0.74 100 100 0.32
CTV95, % 100 100 0.15 100 100 0.40 100 100 0.23 100 100 0.36 100 100 0.40
PTV95, % 96.7 96.1 0.31 98.6 99.1 0.89 96.5 94.8 0.26 96.5 95.0 0.43 97.0 97.3 0.37
Lung V5, % 50.5 51.8 0.31 50.0 51.2 0.14 50.5 52.6 0.68 52.5 52.2 0.20 50.0 51.2 0.95
Lung V20, % 29.1 28.9 0.24 29.3 26.3 0.04 28.9 29.6 0.86 29.5 29,6 0.61 27.9 27.9 0.11
Lung mean dose, Gy 18.1 18.5 0.45 18.2 16.4 0.04 18.1 18.6 0.68 18.2 18.5 0.96 16.1 18.6 0.11
Esophagus mean dose, Gy 28.2 28.4 0.24 26.7 24.0 0.89 28.7 28.4 0.20 31.4 32.3 0.42 22.2 22.2 0.44
Esophagus max, Gy 74.3 76.5 0.56 68.9 67.3 0.22 75.2 76.6 0.27 75.2 76.4 0.97 73.3 76.6 0.21
Esophagus V50, % 29.0 28.9 0.08 32.4 20.9 0.22 28.9 30.1 0.02 32.1 31.7 0.10 23.8 23.5 0.34
Heart mean dose, Gy 11.1 11.3 0.29 6.3 6.0 0.22 12.6 13.3 0.49 12.6 15.4 0.43 6.6 10.2 0.44
Heart V40, % 8.6 7.0 0.63 4.6 3.5 0.17 9.4 8.84 0.86 11.2 10.8 0.70 3.5 6.8 0.50
Spinal cord max, Gy 42.3 42.7 0.19 42.7 41.7 0.5 42.3 42.8 0.25 42.8 43.1 0.33 39.2 41.7 0.37
  1. Abbreviations: GTV gross tumor volume, CTV clinical target volume, PTV planning target volume.
  2. *P values calculated with Wilcoxon matched-pairs signed-ranks test. Bolded p values are <0.05 and are taken as statistically significant.