| | |
Pre-Tx
|
Acute
†
|
Late
‡
|
Last late
§
|
|---|
|
Toxicity
|
Grade
|
n (%)
|
n (%)
|
n (%)**
|
n (%)**
|
|---|
|
Pain
|
0
|
24 (48)
|
-
|
36 (77)
|
42 (90)
|
| |
1
|
16 (32)
|
3 (6)
|
5 (11)
|
2 (4)
|
| |
2
|
10 (20)
|
34 (68)
|
4 (8)
|
1 (2)
|
| |
3
|
-
|
13 (26)
|
2 (4)
|
2 (4)
|
|
Dermatitis
|
0
|
50 (100)
|
1 (2)
|
46 (98)
|
47 (100)
|
| |
1
|
-
|
5 (10)
|
1 (2)
|
-
|
| |
2
|
-
|
31 (62)
|
-
|
-
|
| |
3
|
-
|
13 (26)
|
-
|
-
|
|
Mucositis
|
0
|
50 (100)
|
3 (6)
|
46 (98)
|
47 (100)
|
| |
1
|
-
|
8 (16)
|
1 (2)
|
-
|
| |
2
|
-
|
31 (74)
|
-
|
-
|
| |
3
|
-
|
8 (16)
|
-
|
-
|
|
Dysphagia
|
0
|
20 (40)
|
1 (2)
|
28 (60)
|
37 (78)
|
| |
1
|
23 (46)
|
5 (10)
|
7 (15)
|
5 (11)
|
| |
2
|
4 (8)
|
27 (54)
|
8 (17)
|
5 (11)
|
| |
3
|
3 (6)
|
17 (34)
|
4 (8)
|
-
|
|
Xerostomia
|
0
|
50 (100)
|
37 (74)
|
23 (49)
|
40 (85)
|
| |
1
|
-
|
9 (18)
|
21 (45)
|
6 (13)
|
| |
2
|
-
|
4 (8)
|
3 (6)
|
1 (2)
|
| |
3
|
-
|
-
|
-
|
-
|
|
Osteonecrosis
|
0
|
50 (100)
|
49 (98)
|
45 (96)
|
46 (98)
|
| |
1
|
-
|
-
|
-
|
-
|
| |
2
|
-
|
-
|
-
|
-
|
| |
3
|
-
|
1 (2)
|
2 (4)
|
1 (2)
|
|
Highest*
|
0
|
13 (26)
|
-
|
15 (32)
|
30 (64)
|
| |
1
|
20 (40)
|
-
|
14 (30)
|
9 (19)
|
| |
2
|
14 (28)
|
19 (38)
|
11 (23)
|
6 (13)
|
| |
3
|
3 (6)
|
31 (62)
|
7 (15)
|
2 (4)
|
-
Abbreviations:
Pre-Tx pre-treatment morbidity, *The highest morbidity/toxicity in a patient was counted as a single event; †During therapy and until 3 months after completion; ‡Maximal late toxicity > 3 months after completion of therapy; §Incidence of late toxicity at last follow-up visit. **3 patients died within the acute toxicity period.
