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Table 4 Pre-treatment morbidity and acute and late toxicity

From: Definitive intensity modulated radiotherapy in locally advanced hypopharygeal and laryngeal squamous cell carcinoma: mature treatment results and patterns of locoregional failure

  

Pre-Tx

Acute

Late

Last late §

Toxicity

Grade

n (%)

n (%)

n (%)**

n (%)**

Pain

0

24 (48)

-

36 (77)

42 (90)

 

1

16 (32)

3 (6)

5 (11)

2 (4)

 

2

10 (20)

34 (68)

4 (8)

1 (2)

 

3

-

13 (26)

2 (4)

2 (4)

Dermatitis

0

50 (100)

1 (2)

46 (98)

47 (100)

 

1

-

5 (10)

1 (2)

-

 

2

-

31 (62)

-

-

 

3

-

13 (26)

-

-

Mucositis

0

50 (100)

3 (6)

46 (98)

47 (100)

 

1

-

8 (16)

1 (2)

-

 

2

-

31 (74)

-

-

 

3

-

8 (16)

-

-

Dysphagia

0

20 (40)

1 (2)

28 (60)

37 (78)

 

1

23 (46)

5 (10)

7 (15)

5 (11)

 

2

4 (8)

27 (54)

8 (17)

5 (11)

 

3

3 (6)

17 (34)

4 (8)

-

Xerostomia

0

50 (100)

37 (74)

23 (49)

40 (85)

 

1

-

9 (18)

21 (45)

6 (13)

 

2

-

4 (8)

3 (6)

1 (2)

 

3

-

-

-

-

Osteonecrosis

0

50 (100)

49 (98)

45 (96)

46 (98)

 

1

-

-

-

-

 

2

-

-

-

-

 

3

-

1 (2)

2 (4)

1 (2)

Highest*

0

13 (26)

-

15 (32)

30 (64)

 

1

20 (40)

-

14 (30)

9 (19)

 

2

14 (28)

19 (38)

11 (23)

6 (13)

 

3

3 (6)

31 (62)

7 (15)

2 (4)

  1. Abbreviations: Pre-Tx pre-treatment morbidity, *The highest morbidity/toxicity in a patient was counted as a single event; During therapy and until 3 months after completion; Maximal late toxicity > 3 months after completion of therapy; §Incidence of late toxicity at last follow-up visit. **3 patients died within the acute toxicity period.