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Table 4 Pre-treatment morbidity and acute and late toxicity

From: Definitive intensity modulated radiotherapy in locally advanced hypopharygeal and laryngeal squamous cell carcinoma: mature treatment results and patterns of locoregional failure

   Pre-Tx Acute Late Last late §
Toxicity Grade n (%) n (%) n (%)** n (%)**
Pain 0 24 (48) - 36 (77) 42 (90)
  1 16 (32) 3 (6) 5 (11) 2 (4)
  2 10 (20) 34 (68) 4 (8) 1 (2)
  3 - 13 (26) 2 (4) 2 (4)
Dermatitis 0 50 (100) 1 (2) 46 (98) 47 (100)
  1 - 5 (10) 1 (2) -
  2 - 31 (62) - -
  3 - 13 (26) - -
Mucositis 0 50 (100) 3 (6) 46 (98) 47 (100)
  1 - 8 (16) 1 (2) -
  2 - 31 (74) - -
  3 - 8 (16) - -
Dysphagia 0 20 (40) 1 (2) 28 (60) 37 (78)
  1 23 (46) 5 (10) 7 (15) 5 (11)
  2 4 (8) 27 (54) 8 (17) 5 (11)
  3 3 (6) 17 (34) 4 (8) -
Xerostomia 0 50 (100) 37 (74) 23 (49) 40 (85)
  1 - 9 (18) 21 (45) 6 (13)
  2 - 4 (8) 3 (6) 1 (2)
  3 - - - -
Osteonecrosis 0 50 (100) 49 (98) 45 (96) 46 (98)
  1 - - - -
  2 - - - -
  3 - 1 (2) 2 (4) 1 (2)
Highest* 0 13 (26) - 15 (32) 30 (64)
  1 20 (40) - 14 (30) 9 (19)
  2 14 (28) 19 (38) 11 (23) 6 (13)
  3 3 (6) 31 (62) 7 (15) 2 (4)
  1. Abbreviations: Pre-Tx pre-treatment morbidity, *The highest morbidity/toxicity in a patient was counted as a single event; During therapy and until 3 months after completion; Maximal late toxicity > 3 months after completion of therapy; §Incidence of late toxicity at last follow-up visit. **3 patients died within the acute toxicity period.