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Table 2 Treatment outcome analysis

From: Definitive intensity modulated radiotherapy in locally advanced hypopharygeal and laryngeal squamous cell carcinoma: mature treatment results and patterns of locoregional failure

Factor Associated level Cox regression analysis: hazard ratio (95% CI) (p-value)
   LRC OS
Univariate analysis    
 Age (years) >60 0.86 (0.26, 2.817) (0.80) 1.96 (0.76, 5.07) (0.17)
 Sex Male 1.14 (0.15, 8.91) (0.90) 0.97 (0.23, 4.16) (0.96)
 Localisation Larynx 1.29 (0.39, 4.24) (0.67) 1.04 (0.44, 2.45) (0.94)
 T-classification cT3-4 1.29 (0.16, 10.06) (0.81) 0.53 (0.18, 1.58) (0.26)
 N-classification c/pN2b-3 1.13 (0.33, 3.87) (0.84) 0.78 (0.33, 1.83) (0.57)
 AJCC stage IV 0.90 (0.24, 3.40) (0.88) 0.91 (0.35, 2.35) (0.91)
 Grading G3 0.88 (0.26, 3.01) (0.84) 0.75 (0.30, 1.85) (0.53)
 Neck Dissection yes 1.48 (0.45, 4.86) (0.52) 0.19 (0.51, 2.81) (0.69)
 Duration RT >55 days 1.08 (0.23, 5.01) (0.92) 0.70 (0.21, 2.40) (0.57)
Multivariate analysis    
 Age (years) >60 0.93 (0.27, 3.39) (0.93) 2.37 (0.83, 6.73) (0.11)
 Sex Male 1.28 (0.13, 12.43) (0.83) 0.79 (0.14, 4.42) (0.79)
 Localisation Larynx 1.31 (0.33, 5.12) (0.70) 1.32 (0.46, 3.75) (0.60)
 T-classification cT3-4 1.51 (0.14, 10.79) (0.73) 0.50 (0.12, 2.05) (0.26)
 N-classification c/pN2b-3 1.26 (0.13, 12.32) (0.85) 0.55 (0.15, 2.02) (0.57)
 AJCC stage IV 0.51 (0.05, 5.38) (0.57) 0.92 (0.45, 8.15) (0.38)
 Grading G3 1.13 (0.28, 4.57) (0.87) 0.99 (0.36, 2.74) (0.98)
 Neck Dissection yes 1.83 (0.34, 9.89) (0.49) 1.54 (0.52, 4.55) (0.43)
 Duration RT >55 days 1.11 (0.22, 5.50) (0.90) 0.65 (0.17, 2.43) (0.52)
  1. Abbreviations: LRC Locoregional control, OS Overall survival, CI confidence interval.