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Table 5 Multivariable Cox regression models for the influence of categorized weight loss on survival outcomes

From: Impact of weight loss on survival after chemoradiation for locally advanced head and neck Cancer: secondary results of a randomized phase III trial (SAKK 10/94)

Variable

Cox regression analysis, hazard ratio (95% confidence interval) (p-value)

 

TTF

LRRFS

DMFS

CSS

OS

Multivariable analysis*

     

Treatment arm: RT only vs. combined

1.3 (1.0-1.8) (0.08)

1.6 (1.1-2.4) (0.02)

1.9 (1.2-3.0) (0.006)

1.9 (1.2-3.0) (0.006)

1.4 (1.0-2.0) (0.05)

Performance status: 1 + 2 vs. 0

 

1.5 (1.0-2.2) (0.06)

1.6 (1.0-2.4) (0.05)

1.8 (0.9-3.3) (0.08)

 

Tumor classification: cT3-4 vs. cT1-2

Nodal classification: cN2-3 vs. cN0-1

1.3 (0.9-1.8) (0.1)

1.4 (1.0-2.1) (0.08)

1.5 (1.0-2.4) (0.07)

1.5 (1.0-2.4) (0.07)

 

Weight loss before treatment (<=5% vs. none)

1.4 (0.9-2.1) (0.12)

1.5 (0.9-2.5) (0.08)

1.6 (0.9-2.9) (0.1)

1.1 (0.6-1.9) (0.9)

1.3 (0.9-2.0) (0.2)

Weight loss before treatment (>5-10% vs. none)

1.5 (1.0-2.3) (0.06)

1.2 (0.7-2.0) (0.5)

1.8 (1.0-3.2) (0.03)

1.6 (0.9-2.9) (0.08)

1.7 (1.1-2.6) (0.02)

Weight loss before treatment (>10% vs. none)

2.8 (1.7-4.5) (<0.001)

2.5 (1.4-4.5) (0.002)

3.1 (1.6-6.1) (<0.001)

2.8 (1.5-5.4) (0.002)

3.2 (2.0-5.3) (<0.001)

  1. *after backward selection with level 0.1.