Table 1 Comparison of characteristics according to ACI in all patients
With ACI (n = 192) | Without ACI (n = 1,054) | p -value ‡ | ||
|---|---|---|---|---|
Age (yr) | Mean ± SD | 57.6 ± 11.3 | 58.2 ± 10.8 | 0.462 |
Gender | Male | 114 (59.4) | 718 (68.1) | 0.018 |
Female | 78 (40.6) | 336 (31.9) | ||
Distance from anal verge (cm) | Mean ± SD | 2.0 ± 0.9 | 6.9 ± 2.1 | <0.001 |
Histological grade* | Low | 171 (90.0) | 989 (96.2) | <0.001 |
High | 19 (10.0) | 39 (3.8) | ||
(Not specified = 28) | ||||
Clinical stage | cStage II | 42 (21.9) | 213 (20.2) | 0.599 |
cStage III | 150 (78.1) | 841 (79.8) | ||
Pathological stage | ypStage 0 | 26 (13.5) | 104 (9.9) | 0.001 |
ypStage I | 47 (24.5) | 176 (16.7) | ||
pStage II/ypStage II | 54 (28.1) | 299 (28.4) | ||
pStage III/ypStage III | 65 (33.9) | 475 (45.1) | ||
CRT timing | Preoperative CRT | 168 (87.5) | 709 (67.3) | <0.001 |
Postoperative CRT | 24 (12.5) | 345 (32.7) | ||
Concurrent chemotherapy | Fluoropyrimidine alone | 166 (86.5) | 960 (91.8) | 0.018 |
Irinotecan or oxaliplatin-based | 26 (13.5) | 86 (8.2) | ||
(None = 8) | ||||
Surgery | Sphincter-sparing surgery | 64 (33.3) | 1,016 (96.4) | <0.001 |
Abdominoperineal resection | 128 (66.7) | 38 (3.6) | ||
CRM | Negative (>0.1 cm) | 154 (80.2) | 890 (85.3) | 0.071 |
Positive (≤0.1 cm) | 38 (19.8) | 153 (14.7) | ||
(Not specified = 11) | ||||
Postoperative chemotherapy | Yes | 175 (91.1) | 962 (91.3) | 0.955 |
No† | 17 (8.9) | 92 (8.7) |