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Table 3 Multivariate analysis in relation to overall survival and disease-free survival

From: Baseline neutrophil-lymphocyte ratio (≥2.8) as a prognostic factor for patients with locally advanced rectal cancer undergoing neoadjuvant chemoradiation

Patient characteristics Overall survival Disease-free survival
HR 95%CI P-value HR 95%CI P-value
Tumor stage before CRT      
II       
III 3.846 0.502-29.465 0.195 2.045 0.724-5.778 0.177
NLR before CRT       
Low (<2.8)       
High (≥2.8) 2.123 1.140-3.954 0.018 1.363 0.840-2.214 0.210
CEA, ng/ml       
<5       
≥5 1.364 0.698-2.665 0.363 1.427 0.876-2.324 0.153
Surgical procedure       
Curative surgery       
Palliative surgery 1.289 0.488-3.401 0.608 1.472 0.680-3.185 0.327
Lymphatic or vascular invasion      
No       
Yes 1.419 0.618-3.257 0.409 1.368 0.712-2.629 0.347
ypTNM staging       
ypT0-2 N0       
ypT3-4/N+ 3.928 1.651-9.345 0.002 3.477 1.857-6.509 <0.001
TRG score       
0-1       
2-3 0.904 0.464-1.760 0.766 1.027 0.626-1.684 0.916
Adjuvant chemotherapy      
Yes     
No 3.506 1.251-9.827 0.017