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Table 2 Univariate analysis in relation to overall survival and disease-free survival

From: Baseline neutrophil-lymphocyte ratio (≥2.8) as a prognostic factor for patients with locally advanced rectal cancer undergoing neoadjuvant chemoradiation

Patient characteristics Overall survival Disease-free survival
HR 95%CI P-value HR 95%CI P-value
Age, years       
<60       
≥60 0.954 0.488-1.865 0.891 0.729 0.431-1.234 0.240
Gender       
Female       
Male 1.029 0.492-2.153 0.939 0.992 0.575-1.714 0.978
Tumor stage before CRT      
II       
III 7.237 0.992-52.812 0.051 3.468 1.262-9.532 0.016
Tumor location       
Low       
Middle-high 1.321 0.720-2.426 0.368 1.025 0.635-1.656 0.920
NLR before CRT       
Low (<2.8)       
High (≥2.8) 2.526 1.384-4.610 0.003 1.662 1.037-2.664 0.035
Platelets count, ×10 9 /l      
<300       
≥300 0.655 0.258-1.664 0.373 0.813 0.417-1.587 0.544
CEA, ng/ml       
<5       
≥5 2.014 1.092-3.715 0.025 1.727 1.081-2.761 0.022
RT dose, Gy       
45-50       
>50 0.801 0.403-1.594 0.527 0.716 0.432-1.185 0.193
Surgical procedure       
Curative surgery       
Palliative surgery 2.383 0.994-5.713 0.052 2.2 1.048-4.616 0.037
Lymphatic or vascular invasion
No       
Yes 2.346 1.085-5.073 0.03 2.274 1.221-4.238 0.010
Neural invasion       
No       
Yes 1.254 0.557-2.824 0.585 1.382 0.757-2.525 0.293
Circumferential resection margin
Negtive       
Positive 1.956 0.470-8.148 0.357 1.454 0.356-5.936 0.602
ypTNM staging       
ypT0-2 N0       
ypT3-4/N+ 4.223 1.953-9.133 <0.001 4.204 2.337-7.562 <0.001
TRG score       
0-1       
2-3 1.897 1.031-3.491 0.040 1.714 1.076-2.731 0.023
Adjuvant chemotherapy      
Yes       
No 2.354 0.982-5.639 0.055 1.294 0.592-2.826 0.518