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Table 2 Univariate and multivariate analysis of factors associated with locoregional recurrence free survival in patients without postmastectomy radiotherapy

From: Number of negative lymph nodes can predict survival of breast cancer patients with four or more positive lymph nodes after postmastectomy radiotherapy

Characteristic Univariate analysis Multivariate analyses
HR 95% CI p HR 95% CI p
Age, years (<35 vs. ≥35) 0.707 0.302-1.656 0.425
Menopausal status (premenopausal vs. postmenopausal) 0.473 0.244-0.919 0.027* 0.494 0.254-0.961 0.038*
Tumor size (T3-T4 vs. T1-T2) 2.708 1.529-4.797 0.001* 2.193 1.231-3.909 0.008*
Nodal stage (N3 vs. N2) 1.991 1.160-3.418 0.012* 1.577 0.762-3.264 0.219
ER status (positive vs. negative) 0.891 0.516-1.530 0.676
PR status (positive vs. negative) 1.278 0.700-2.222 0.452
HER2 status (positive vs. negative) 1.032 0.595-1.790 0.912
Breast cancer subtype
  (luminal B vs. luminal A) 1.309 0.676-2.533 0.424
  (HER2 positive vs. luminal A) 0.855 0.368-1.988 0.716
  (triple negative vs. luminal A) 1.409 0.632-3.137 0.402
  Number of NLNs, n (12–39 vs. 0–12) 0.111 0.027-0.458 0.002 0.132 0.032-0.547 0.005
LNR
  (0.21-0.65 vs. < 0.20) 3.608 0.859-15.152 0.080 2.950 0.646-13.465 0.163
  (> 0.65 vs. < 0.20) 7.473 1.759-31.755 0.006* 3.376 0.773-14.750 0.106
  1. ER, estrogen receptor; PR, progesterone receptor; Her-2, human epidermal growth factor receptor-2; NLNs, negative lymph nodes; LNR, lymph nodes ratio.
  2. *p < 0.05 indicates a significant difference.