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Table 2 Univariate and multivariate analysis of factors associated with locoregional recurrence free survival in patients without postmastectomy radiotherapy

From: Number of negative lymph nodes can predict survival of breast cancer patients with four or more positive lymph nodes after postmastectomy radiotherapy

Characteristic

Univariate analysis

Multivariate analyses

HR

95% CI

p

HR

95% CI

p

Age, years (<35 vs. ≥35)

0.707

0.302-1.656

0.425

Menopausal status (premenopausal vs. postmenopausal)

0.473

0.244-0.919

0.027*

0.494

0.254-0.961

0.038*

Tumor size (T3-T4 vs. T1-T2)

2.708

1.529-4.797

0.001*

2.193

1.231-3.909

0.008*

Nodal stage (N3 vs. N2)

1.991

1.160-3.418

0.012*

1.577

0.762-3.264

0.219

ER status (positive vs. negative)

0.891

0.516-1.530

0.676

PR status (positive vs. negative)

1.278

0.700-2.222

0.452

HER2 status (positive vs. negative)

1.032

0.595-1.790

0.912

Breast cancer subtype

  (luminal B vs. luminal A)

1.309

0.676-2.533

0.424

  (HER2 positive vs. luminal A)

0.855

0.368-1.988

0.716

  (triple negative vs. luminal A)

1.409

0.632-3.137

0.402

  Number of NLNs, n (12–39 vs. 0–12)

0.111

0.027-0.458

0.002

0.132

0.032-0.547

0.005

LNR

  (0.21-0.65 vs. < 0.20)

3.608

0.859-15.152

0.080

2.950

0.646-13.465

0.163

  (> 0.65 vs. < 0.20)

7.473

1.759-31.755

0.006*

3.376

0.773-14.750

0.106

  1. ER, estrogen receptor; PR, progesterone receptor; Her-2, human epidermal growth factor receptor-2; NLNs, negative lymph nodes; LNR, lymph nodes ratio.
  2. *p < 0.05 indicates a significant difference.