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Table 3 Univariate analysis of volumetric parameter cut-off values compared to survival outcomes

From: The effect of tumor volume and its change on survival in stage III non-small cell lung cancer treated with definitive concurrent chemoradiotherapy

Variable*   n 3Y LRPFS (%) p 3Y PFS (%) p 3Y OS (%) p
Sex Male 137 41.6 0.251 22.9 0.589 36.6 0.017
  Female 20 63.3   23.8   55.0  
Age ≤ 60 y 65 41.3 0.563 20.5 0.444 35.5 0.307
  > 60 y 92 47.9   25.0   37.1  
ECOG 0 39 32.6 0.611 15.0 0.318 34.4 0.721
  1-2 118 47.8   25.5   36.8  
Histology SqCC 86 36.0 0.048 24.0 0.517 32.0 0.151
  Others 71 56.3   19.2   41.8  
  ADC 52 52.5 0.110 19.2 0.596 45.0 0.335
  Others 105 40.5   24.9   34.6  
T stage 1-2 79 56.4 0.034 25.2 0.281 43.8 0.106
  3-4 78 33.8   20.7   28.7  
N stage 0-2 81 49.4 0.448 29.2 0.108 37.0 0.686
  3 76 39.5   17.0   35.6  
Stage IIIA 49 56.5 0.084 33.1 0.041 42.0 0.705
  IIIB 108 39.8   18.6   33.7  
GTVpre (Continuous) (95% CI) (1.001) (0.330) (1.003) (<0.001) (1.001) (0.019)
   (HR) (0.999–1.002)   (1.002–1.004)   (1.000–1.002)  
  ≤ 50 cm3 33 75.0 0.001 42.5 0.001 65.7 < 0.001
  > 50 cm3 124 34.8   17.1   28.4  
GTVpost (Continuous) (95% CI) (1.004) (0.189) (1.015) (<0.001) (1.006) (0.008)
   (HR) (0.998–1.010)   (1.008–1.021)   (1.002–1.011)  
  ≤ 20 cm3 68 53.3 0.165 32.4 0.004 43.2 0.015
  > 20 cm3 89 36.7   15.5   31.0  
VRR (Continuous) (95% CI) (1.011) (0.126) (1.008) (0.139) (1.013) (0.028)
   (HR) (0.997–1.025)   (0.997–1.020)   (1.001–1.025)  
  ≤ 50% 21 68.2 0.042 39.6 0.054 64.6 0.004
  >50% 136 40.6   20.2   32.2  
  1. Abbreviations: ADC Adenocarcinoma, CI Confidence interval, ECOG Eastern Cooperative Oncology Group, GTV pre Initial gross tumor volume, GTV post Follow-up gross tumor volume, HR Harzard ratio, LRPFS locoregional progression-free survival rate, OS Overall survival rate, SqCC Squamous cell carcinoma, VRR Reduction ratio of gross tumor volume.
  2. *All variables are categorical, unless being noted as “continuous”.
  3. The log-rank test and the Cox proportional hazards model were used for categorical and continuous variables, respectively.