| 18 months |  |  |  | 36 months |  |  |  | 54 months |  |  |  |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Endpoint | Variable | P | P* | OR (CI) | Variable | P | P* | OR (CI) | Variable | P | P* | OR (CI) |
Proctitis | Orientation (prone vs supine) | 0.051 | NS | 2.467 (0.996–6.111) | Conformity index (continuous) | 0.032 | NS | 3.157 (1.102–9.046) |  |  |  |  |
 | Mean CSA (per cm2) | 0.062 | NS | 0.926 (0.854–1.004) |  |  |  |  |  |  |  |  |
Rectal bleeding |  |  |  |  | Dose calculation algorithm (type-b vs type-a) | 0.011 | NS | 0.479 (0.271–0.847) | Dose calculation algorithm (type-b vs type-a) | 0.055 | NS | 0.561 (0.311–1.013) |
 |  |  |  |  | Rectal width (per cm) | 0.026 | NS | 0.726 (0.548–0.963) |  |  |  |  |
 |  |  |  |  | Prescription dose (per Gy) | 0.021 | NS | 0.876 (1.017–1.158) |  |  |  |  |
 |  |  |  |  | PTV (per cm3) | 0.061 | NS | 1.003 (1–1.007) |  |  |  |  |
Stool frequency | Rectal intervention (bulking agent vs no intervention) | 0.049 | NS | 0.78 (0.436–1.395) | Dose calculation algorithm (type-b vs type-a) | 0.006 | 0.039 | 0.435 (0.242–0.783) | Dose calculation algorithm (type-b vs type-a) | 0.079 | NS | 0.554 (0.287– 1.07) |
 | Rectal intervention (laxative vs no intervention) | 0.053 | NS | 1.749 (0.801–3.819) | Rectal intervention (laxative vs no intervention) | 0.003 | 0.039 | 3.639 (1.502–8.818) | Number of beam (per 1 beam) | 0.083 | NS | 0.692 (0.457–1.049) |
 | PTV (per cm3) | 0.022 | NS | 1.004 (1.001–1.007) | PTV (per cm3) | 0.059 | NS | 1.004 (1–1.007) | PTV (per cm3) | 0.008 | NS | 1.007 (1.002–1.012) |
 | PTV–rectal separation (per cm) | 0.061 | NS | 1.84 (0.971–3.486) | Conformity index (continuous) | 0.049 | NS | 0.293 (0.087–0.993) |  |  |  |  |
Tenesmus | Number of beam (per 1 beam) | 0.085 | NS | 0.775 (0.581–1.036) |  |  |  |  |  |  |  |  |
 | Rectal intervention (laxative vs no intervention) | 0.072 | NS | 2.058 (0.971–4.364) |  |  |  |  |  |  |  |  |