Figure 2

Behavioral test. (A) The distance all groups of rats traveled in the central region was determined in the open field test. No significant difference was observed (P > 0.05). (B) The six groups did not show any statistical difference in the total time of activity in the open field test (P > 0.05). (C) The six groups showed similar swimming speeds in the Morris water maze test (P > 0.05). (D) A single dose of 20 Gy WBI significantly increased latency, e.g. the time they needed to reach the hidden platform in the MWM test (P < 0.05 vs. unirradiated control). And minocycline decreased the latency back to the control level (P > 0.05 vs. unirradiated controls, but P < 0.05 vs. irradiated group). (E) No significant difference in the percentage of the target quadrant exploring time among the six groups (P > 0.05). The number of rats: n = 18/group except the SCN and SCM groups which had n = 12/group.