Table 2 Local control of the irradiated brain metastases (univariate analysis)
At 6 months (%) | At 12 months (%) | P -value | |
|---|---|---|---|
Treatment regimen | |||
Radiosurgery alone (n = 30) | 86 | 79 | |
Radiosurgery + WBI (n = 28) | 96 | 92 | 0.59 |
Radiosurgery dose | |||
<20 Gy (n = 23) | 83 | 78 | |
≥20 Gy (n = 35) | 97 | 90 | 0.23 |
Age | |||
≤59 years (n = 34) | 97 | 91 | |
≥60 years (n = 24) | 83 | 77 | 0.066 |
ECOG performance score | |||
0-1 (n = 40) | 95 | 87 | |
2 (n = 18) | 82 | 82 | 0.69 |
Number of cerebral metastases | |||
1 (n = 46) | 91 | 83 | |
2-3 (n = 12) | 92 | 92 | 0.58 |
Maximum diameter of all brain metastases | |||
≤10 mm (n = 28) | 93 | 89 | |
≥11 mm (n = 30) | 90 | 81 | 0.66 |
Site of brain metastases | |||
Supratentorial (n = 39) | 92 | 83 | |
Infratentorial ± supratentorial (n = 19) | 89 | 89 | 0.35 |
Extra-cranial metastases | |||
No (n = 24) | 88 | 79 | |
Yes (n = 34) | 94 | 91 | 0.31 |
Time from breast cancer diagnosis to radiotherapy | |||
≤48 months (n = 30) | 93 | 86 | |
≥49 months (n = 28) | 89 | 85 | 0.61 |