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Table 12 Suggested fractionation regimens for hypo-pharyngeal and laryngeal cancer

From: Technical guidelines for head and neck cancer IMRT on behalf of the Italian association of radiation oncology - head and neck working group

Author

 

D (Gy)

d (Gy)

Fxs

OTT (wks)

Comment

 

CTV1

70

2

35

7

 

Lee et al. [122]

 

70

2.0

35

7

2-years PEG dependent: 15%

Studer et al. [121]

 

69.6

2.11

33

6.5

 

Miah et al. [123]

 

63

2.25

28

5.6

Arm 1 (DL1)

  

67.2

2.4

28

5.6

Arm 2 (DL2)

 

CTV2

63

1.8

35

7

 

Lee et al. [122]

 

59.5

1.7

35

7

 
 

CTV3

58.1

1.66

35

7

 

Lee et al. [122]

 

56.0

1.6

35

6.5

 

Studer et al. [121]

 

54

1.64

33

6.5

 

Miah et al. [123]

 

51.8

1.85

28

5.5

Acute Grade 3 (G3) dysphagia was higher in DL2 (87% DL2 vs. 59% DL1)

  

56

2

28

5.5