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Table 12 Suggested fractionation regimens for hypo-pharyngeal and laryngeal cancer

From: Technical guidelines for head and neck cancer IMRT on behalf of the Italian association of radiation oncology - head and neck working group

Author   D (Gy) d (Gy) Fxs OTT (wks) Comment
  CTV1 70 2 35 7  
Lee et al. [122]   70 2.0 35 7 2-years PEG dependent: 15%
Studer et al. [121]   69.6 2.11 33 6.5  
Miah et al. [123]   63 2.25 28 5.6 Arm 1 (DL1)
   67.2 2.4 28 5.6 Arm 2 (DL2)
  CTV2 63 1.8 35 7  
Lee et al. [122]   59.5 1.7 35 7  
  CTV3 58.1 1.66 35 7  
Lee et al. [122]   56.0 1.6 35 6.5  
Studer et al. [121]   54 1.64 33 6.5  
Miah et al. [123]   51.8 1.85 28 5.5 Acute Grade 3 (G3) dysphagia was higher in DL2 (87% DL2 vs. 59% DL1)
   56 2 28 5.5