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Table 2 The average maximum and mean dose reduction (%) of the OARs except the normal brain

From: Feasibility of extreme dose escalation for glioblastoma multiforme using 4π radiotherapy

Normal tissue comparison 4πPTV PD 4πPTV 100Gy 4πGTV 100Gy 4πPTV PD+5mm
Average Max Dose Reduction (%)
  % p-value % p-value % p-value % p-value
Brainstem 47.01 0.003 7.18 0.898 27.65 0.123 30.66 0.003
Chiasm 84.73 <0.001 72.12 <0.001 86.74 <0.001 77.06 <0.001
Spinal Cord 73.98 0.007 39.79 0.240 84.22 0.006 51.94 0.064
Left Eye 83.89 <0.001 69.03 <0.001 87.03 <0.001 66.86 <0.001
Right Eye 88.01 <0.001 76.16 <0.001 88.11 <0.001 84.12 <0.001
Left Lens 98.43 <0.001 94.96 <0.001 98.63 <0.001 97.53 <0.001
Right Lens 97.74 <0.001 93.88 <0.001 98.82 <0.001 97.59 <0.001
L Opt Nrv 87.12 <0.001 74.31 <0.001 88.45 0.002 72.44 <0.001
R Opt Nrv 89.93 <0.001 80.42 <0.001 91.33 0.005 75.72 <0.001
L Cochlea 82.45 <0.001 64.87 0.005 84.15 0.003 44.94 0.067
R Cochlea 93.58 <0.001 85.19 0.001 93.10 <0.001 77.97 0.007
  Average Mean Dose Reduction (%)
Brainstem 60.96 0.002 38.08 0.067 57.77 <0.001 51.87 0.002
Chiasm 95.30 <0.001 88.88 <0.001 96.23 <0.001 92.27 <0.001
Spinal Cord 92.43 <0.001 80.07 <0.001 98.08 <0.001 71.51 0.014
Left Eye 94.61 <0.001 85.66 <0.001 96.49 <0.001 89.78 <0.001
Right Eye 95.94 <0.001 87.95 <0.001 96.69 <0.001 94.24 <0.001
Left Lens 99.23 <0.001 97.11 <0.001 99.44 <0.001 98.56 <0.001
Right Lens 99.10 <0.001 96.56 <0.001 99.47 <0.001 98.72 <0.001
L Opt Nrv 95.98 <0.001 87.66 <0.001 96.96 <0.001 88.46 <0.001
R Opt Nrv 97.48 <0.001 94.08 <0.001 98.42 <0.001 93.09 <0.001
L Cochlea 90.34 <0.001 78.41 0.002 85.92 0.002 60.16 0.037
R Cochlea 96.83 <0.001 92.81 0.003 97.79 <0.001 90.83 0.002