Feasibility of extreme dose escalation for glioblastoma multiforme using 4π radiotherapy

Radiation Oncology

Table 2 The average maximum and mean dose reduction (%) of the OARs except the normal brain

Normal tissue comparison	4πPTV _PD		4πPTV _100Gy		4πGTV _100Gy		4πPTV _PD+5mm
Normal tissue comparison	Average Max Dose Reduction (%)
	%	p-value	%	p-value	%	p-value	%	p-value
Brainstem	47.01	0.003	7.18	0.898	27.65	0.123	30.66	0.003
Chiasm	84.73	<0.001	72.12	<0.001	86.74	<0.001	77.06	<0.001
Spinal Cord	73.98	0.007	39.79	0.240	84.22	0.006	51.94	0.064
Left Eye	83.89	<0.001	69.03	<0.001	87.03	<0.001	66.86	<0.001
Right Eye	88.01	<0.001	76.16	<0.001	88.11	<0.001	84.12	<0.001
Left Lens	98.43	<0.001	94.96	<0.001	98.63	<0.001	97.53	<0.001
Right Lens	97.74	<0.001	93.88	<0.001	98.82	<0.001	97.59	<0.001
L Opt Nrv	87.12	<0.001	74.31	<0.001	88.45	0.002	72.44	<0.001
R Opt Nrv	89.93	<0.001	80.42	<0.001	91.33	0.005	75.72	<0.001
L Cochlea	82.45	<0.001	64.87	0.005	84.15	0.003	44.94	0.067
R Cochlea	93.58	<0.001	85.19	0.001	93.10	<0.001	77.97	0.007
	Average Mean Dose Reduction (%)
Brainstem	60.96	0.002	38.08	0.067	57.77	<0.001	51.87	0.002
Chiasm	95.30	<0.001	88.88	<0.001	96.23	<0.001	92.27	<0.001
Spinal Cord	92.43	<0.001	80.07	<0.001	98.08	<0.001	71.51	0.014
Left Eye	94.61	<0.001	85.66	<0.001	96.49	<0.001	89.78	<0.001
Right Eye	95.94	<0.001	87.95	<0.001	96.69	<0.001	94.24	<0.001
Left Lens	99.23	<0.001	97.11	<0.001	99.44	<0.001	98.56	<0.001
Right Lens	99.10	<0.001	96.56	<0.001	99.47	<0.001	98.72	<0.001
L Opt Nrv	95.98	<0.001	87.66	<0.001	96.96	<0.001	88.46	<0.001
R Opt Nrv	97.48	<0.001	94.08	<0.001	98.42	<0.001	93.09	<0.001
L Cochlea	90.34	<0.001	78.41	0.002	85.92	0.002	60.16	0.037
R Cochlea	96.83	<0.001	92.81	0.003	97.79	<0.001	90.83	0.002

ISSN: 1748-717X