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Table 5 Characteristics of the 10 patients with adverse effects after optimal hypofractionated conformal radiotherapy

From: Optimal hypofractionated conformal radiotherapy for large brain metastases in patients with high risk factors: a single-institutional prospective study

  Median (range) Univariate Multivariate
p value (CH model) p value HR 95% CI
Age 69 (59–84) 0.04* (0.03*) 0.14 1.05 0.99-1.11
Sex M: 7, F: 3 0.15 0.08 0.26 0.06-1.18
Tumor location Cerebrum: 9, cerebellum: 1 0.63 0.67 0.91 0.59-1.90
Tumor volume (cm3) 20.5 (10.0-32.9) 0.86 0.34 0.96 0.88-1.05
Prescribed isodose (%) 57 (51–65) 0.77 0.88 0.98 0.79-1.22
Fraction number 6 (5–10) 0.007* (0.004*) 0.007* 2.04 1.21-3.43
SDE of the max. dose (Gy) 48.0 (40.5-55.3) 0.50 0.51 0.94 0.77-1.13
V14 (cm3) 4.7 (3.6-6.1) 0.92 0.88 0.96 0.57-1.61
  1. CH: Cox hazard, HR: Hazard ratio, CI: Confidence interval, *: Significant.