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Table 5 Characteristics of the 10 patients with adverse effects after optimal hypofractionated conformal radiotherapy

From: Optimal hypofractionated conformal radiotherapy for large brain metastases in patients with high risk factors: a single-institutional prospective study

 

Median (range)

Univariate

Multivariate

p value (CH model)

p value

HR

95% CI

Age

69 (59–84)

0.04* (0.03*)

0.14

1.05

0.99-1.11

Sex

M: 7, F: 3

0.15

0.08

0.26

0.06-1.18

Tumor location

Cerebrum: 9, cerebellum: 1

0.63

0.67

0.91

0.59-1.90

Tumor volume (cm3)

20.5 (10.0-32.9)

0.86

0.34

0.96

0.88-1.05

Prescribed isodose (%)

57 (51–65)

0.77

0.88

0.98

0.79-1.22

Fraction number

6 (5–10)

0.007* (0.004*)

0.007*

2.04

1.21-3.43

SDE of the max. dose (Gy)

48.0 (40.5-55.3)

0.50

0.51

0.94

0.77-1.13

V14 (cm3)

4.7 (3.6-6.1)

0.92

0.88

0.96

0.57-1.61

  1. CH: Cox hazard, HR: Hazard ratio, CI: Confidence interval, *: Significant.