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Table 4 Characteristics of the six patients with recurrences after optimal hypofractionated conformal radiotherapy

From: Optimal hypofractionated conformal radiotherapy for large brain metastases in patients with high risk factors: a single-institutional prospective study

  Median (range) Univariate Multivariate
p value p value HR 95% CI
Age 68.5 (56–82) 0.17 0.20 1.09 0.95-1.25
Sex M: 3, F: 3 0.91 0.29 0.23 0.01-3.63
Tumor location Cerebrum (P: 2, F: 2, T: 1, O: 1) 0.85 0.75 1.13 0.53-2.39
Tumor volume (cm3) 18.0 (11.9-24.0) 0.69 0.69 1.04 0.85-1.29
Prescribed isodose (%) 57 (52–66) 0.97 0.73 0.93 0.63-1.37
Fraction number 5 (3–8) 0.89 0.73 0.82 0.27-2.49
SDE of the max. dose (Gy) 48.4 (36.8-54.3) 0.72 0.40 0.85 0.58-1.25
V14 (cm3) 4.9 (3.7-5.1) 0.78 0.90 1.07 0.35-3.32
  1. HR: Hazard ratio, CI: Confidence interval, P: Parietal, F: Frontal, T: Temporal, O: Occipital.