Skip to main content
Figure 1 | Radiation Oncology

Figure 1

From: Optimal hypofractionated conformal radiotherapy for large brain metastases in patients with high risk factors: a single-institutional prospective study

Figure 1

Tumor regression after optimal hypofractionated conformal radiotherapy. A: Gd-enhanced T1-weighted MR images. Lung cancer brain metastasis in a 73-year-old male. A large residual tumor (74.6 cm3) obtained after partial removal due to an impending brain hernia was treated with a marginal dose of 27 Gy in five fractions at an isodose of 56% (left). A significant tumor response with no adverse imaging effects was found four months after the administration of conformal radiotherapy (right). The patients’ left hemi-paresis disappeared, and the KPS improved from 60 to 70. B: Contrast-enhanced CT scans (MR images not available for the pace maker implant). Lung cancer brain metastasis in a 52-year-old female. A tumor in the thalamus (10.6 cm3) with perifocal edema was treated with a marginal dose of 31 Gy in five fractions at an isodose of 63% (left). A tumor response was observed seven months after the administration of conformal radiotherapy (right). The patients’ left hemiparesis was ameliorated, and the KPS improved 60 to 70 (walking with a stick 32 months after treatment). C: Gd-enhanced T1-weighted MR images. Breast cancer brain metastasis in a 70-year-old female. A large tumor in the parietal lobe (23.5 cm3) with perifocal edema was treated with a marginal dose of 35 Gy in eight fractions at an isodose of 57% (left). A tumor response was found two months after treatment, Gerstmann’s syndrome disappeared, and the KPS improved 60 to 70. Marginal recurrence was noted 20 months after the first treatment, and the recurrent lesion (1.7 cm3) was treated with a marginal dose of 20 Gy at an isodose of 69% in single-session radiosurgery (center). A tumor response with no adverse imaging effects was found 34 months after the first treatment (right).

Back to article page