Total (%) | Fractures (%) | Without fractures (%) | ||
---|---|---|---|---|
Number of patients | 37 | 10 | 27 | |
Number of lesions radiated | 47 | 10 | 37 | |
Age | p = 0.16 | |||
Mean (years) | 62.8 | 65.3 | 62.2 | |
Age range (years) | 33 - 93 | 33 - 87 | 33 - 93 | |
Gender | NS | |||
Men | 27 (57.5) | 4 (14.8) | 23 (85.2) | |
Women | 20 (42.5) | 6 (30) | 14 (70) | |
Primary cancer | NS | |||
Lung | 18 (38.3) | 4 (22) | 14 (78) | |
Breast | 11 (23.4) | 3 (27) | 8 (73) | |
Prostate | 10 (21.3) | --- | 10 (100) | p = 0.08 |
Other | 8 (17.0) | 3 (37.5) | 5 (62.5) | |
Corticosteroids | NS | |||
< 1 month | 1 (2.1) | 1 (100) | --- | |
> 1 month and < 6 months | 2 (4.2) | 1 (50) | 1 (50) | |
> 6 months | 0 | --- | --- | |
No | 42 (89.5) | 8 (19) | 34 (81) | |
NA | 2 (4.2) | --- | 2 (100) | |
Biphosphonates | NS | |||
Yes | 21 (44.7) | 4 (19) | 17 (81) | |
No | 21 (44.7) | 4 (19) | 17 (81) | |
NA | 5 (10.6) | 2 (40) | 3 (60) | |
Chemotherapy ongoing | p = 0.03 | |||
Yes | 34 (72.3) | 10 (29) | 24 (71) | |
No | 13 (27.7) | --- | 13 (100) | |
Long bone | NS | |||
Femur | 28 (59.6) | 7 (25) | 21(75) | |
Humerus | 17 (36.2) | 3 (18) | 14(78) | |
Tibia | 2 (4.2) | --- | 2 (100) | |
Locoregional history | NS | |||
Fracture | 2 (4.2) | 1 (50) | 1 (50) | |
Osteoarthritis | 5 (10.5) | --- | 5 (100) | |
No | 40 (85.1) | 9 (23) | 31 (77) | |
Contralateral prosthesis | 4 (8.5) | --- | 4 (100) | NS |
Pain intensification | NS | |||
Yes | 42 (89.4) | 10 (24) | 32 (76) | |
No | 5 (10.6) | --- | 5 (100) | |
a) Radiological parameters | ||||
Number of lesions radiated | 47 | 10 | 37 | |
Localization | NS | |||
Upper third | 43 (91.5) | 9 (21) | 34 (79) | |
Lower third | 4 (8.5) | 1 (25) | 3 (75) | |
Type of metastatic spread | ||||
Well defined | 23 (49.0) | --- | 23 (100) | p = 0.0005 |
Diffuse | 24 (51.0) | 10 (42) | 14 (58) | |
Appearance of the metastatic lesion | ||||
Normal | 2 (4.2) | --- | 2 (100) | p = 0.02 |
Osteolytic | 18 (38.3) | 7 (39) | 11 (61) | |
Mixed | 15 (31.9) | 3 (20) | 12 (80) | |
Osteoblastic | 11 (23.5) | --- | 11 (100) | |
Moth---eaten | 1 (2.1) | --- | 1 (100) | |
Mean dimensions (mm) | ||||
Height | 59.8 | 80.07 | 46.1 | |
CI 95% | (40.5; 79.1) | (50.37; 109.8) | (33.3; 58.9) | p < 0.01 |
Diameter 1 | 32.2 | 48.5 | 27.6 | |
CI 95% | (26.8; 37.5) | (41.8; 55.1) | (22.7; 32.6) | p = 0.01 |
Diameter 2 | 22.9 | 34.2 | 19.8 | |
CI 95% | (18.6; 27.3) | (29.5; 38.8) | (15.3; 24.3) | p = 0.01 |
Circumferential perimeter | 142.6 | 133.1 | 145.2 | p = 0.15 |
CI 95% | (129.9; 155.3) | (127.1; 139.1) | (130.3; 160.1) | |
Cortical thickness | 3.5 | 3.3 | 3.6 | p = 0.27 |
CI 95% | (3.1; 3.9) | (3.2; 3.4) | (3.1; 4.0) | |
Craniocaudal cortical lysis | p < 0.0001 | |||
Mean (mm) | 45.2 | 103.0 | 28.6 | |
CI 95% | (25.3; 65.0) | (85.6; 120.4) | (14.7; 42.6) | |
Cortical lysis threshold | ||||
No | 16(34.0) | --- | 16 (100) | |
< 30 mm | 10 (21.3) | --- | 10 (100) | |
< 30 mm | 21 (44.7) | 10 (47.6) | 11 (52.4) | |
Circumferential cortical lysis | p < 0.0001 | |||
Mean (mm) | 32.3 | 78.6 | 19.8 | |
CI 95% | (22.3; 42.3) | (74.5; 82.6) | (11.6; 28.1) | |
Cortical lysis (%) | ||||
No | 16 (34.0) | --- | 16 (100) | |
< 50% | 21 (44.7) | 2 (9.5) | 19 (90.5) | |
< 50% | 10 (21.3) | 8 (80) | 2 (20) | |
Cortical lysis in thickness | p = 0.0018 | |||
Mean (mm) | 2.2 | 3.3 | 2.0 | |
CI 95% | (1.6; 2.9) | (3.2; 3.4) | (1.2; 2.7) | |
Cortical lysis (%) | ||||
No | 16 (34.0) | --- | 16 (100) | |
0 - 99% | 5 (10.7) | --- | 5 (100) | |
100% | 26 (55.3) | 10 (38.5) | 16 (61.5) | |
Mirels score | P = 0.0005 | |||
≤ 7 | 14 (29.8) | --- | 14 (100) | |
= 8 | 9 (19.1) | --- | 9 (100) | |
≥ 9 | 24 (51.1) | 10 (42) | 14 (58) |