Dynamic simulation of motion effects in IMAT lung SBRT

Zou, Wei; Yin, Lingshu; Shen, Jiajian; Corradetti, Michael N; Kirk, Maura; Munbodh, Reshma; Fang, Penny; Jabbour, Salma K; Simone, Charles B; Yue, Ning J; Rengan, Ramesh; Teo, Boon-Keng Kevin

doi:10.1186/s13014-014-0225-3

Radiation Oncology

Table 2 Motion effect on OAR dose distribution in fifteen patients

From: Dynamic simulation of motion effects in IMAT lung SBRT

Constraints	Difference between 3D planned dose and cumulative 4D doses Mean (min, max)	4D inter-fraction variation Mean (min, max)	Difference between cumulative 4D doses with and without motion Mean (min, max)
Spinal cord
D _max	−0.03 Gy (−0.40 Gy, 0.20 Gy)	−0.05 Gy (0.00 Gy, 0.40 Gy)	−0.03 Gy (−0.30 Gy, 0.50 Gy)
D_ _0.35cc	0.00 Gy (−0.16 Gy, 0.17 Gy)	0.02 Gy (0.00 Gy, 0.05 Gy)	0.03 Gy (−0.12 Gy, 0.24 Gy)
D_ _1.2cc	0.01 Gy (−0.12 Gy, 0.14 Gy)	0.02 Gy (0.00 Gy, 0.06 Gy)	0.03 Gy (−0.13 Gy, 0.18 Gy)
Esophagus
D _max	−0.22 Gy (−1.30 Gy, 0.30 Gy)	−0.19 Gy (0.00 Gy, 0.80 Gy)	−0.37 Gy(−2.60 Gy, 0.30 Gy)
D_ _5cc	−0.06 Gy (−0.83 Gy, 1.37 Gy)	0.07 Gy (0.01 Gy, 0.21 Gy)	−0.16 Gy (−0.89 Gy, 0.30 Gy)
Heart
D _max	−0.51 Gy (−2.00 Gy, 0.90 Gy)	0.27 Gy (0.00 Gy, 0.80 Gy)	−0.63 Gy (−2.5 Gy, 0.90 Gy)
D_ _15cc	−0.18 Gy (−0.69 Gy, 0.92 Gy)	0.08 Gy (0.00 Gy, 0.23 Gy)	−0.38 Gy (−1.54 Gy, 0.33 Gy)
Great vessels
D _max	−0.52 Gy (−1.80 Gy, 6.00 Gy)	0.19 Gy (0.00 Gy, 0.40 Gy)	0.39 Gy (−1.10 Gy, 2.00 Gy)
D_ _10cc	−0.12 Gy (−2.44 Gy, 2.66 Gy)	0.04 Gy (0.00 Gy, 0.13 Gy)	−0.03 Gy (−1.05 Gy, 0.63 Gy)
Trachea
D _max	0.04 Gy (−2.10 Gy, 1.40 Gy)	0.03 Gy (0.00 Gy, 0.40 Gy)	0.13 Gy (0.00 Gy, 1.00 Gy)
D_ _10cc	−0.01 Gy (−0.42 Gy, 0.19 Gy)	0.03 Gy (0.00 Gy, 0.37 Gy)	0.01 Gy (−0.08 Gy, 0.14 Gy)
Bronchus
D _max	0.25 Gy (−2.00 Gy, 4.90 Gy)	0.37 Gy (0.00 Gy, 1.20 Gy)	0.75 Gy (−2.00 Gy, 7.80 Gy)
D_ _10cc	−0.42 Gy (−4.10 Gy, 2.98 Gy)	0.08 Gy (0.00 Gy, 0.25 Gy)	0.30 Gy (−0.40 Gy, 1.59 Gy)
Rib
D _max	−0.58 Gy (−3.00 Gy, 1.50 Gy)	0.29 Gy (0.00 Gy, 1.20 Gy)	−0.54 Gy (−1.50 Gy, 0.60 Gy)
D_ _1cc	−0.19 Gy (−1.58 Gy, 4.64 Gy)	0.10 Gy (0.01 Gy, 0.32 Gy)	−0.33 Gy (−0.99 Gy, 0.44 Gy)
Total lung
V_ _20Gy	0.02% (−0.87%, 0.66%)	0.02% (0.00%, 0.14%)	−0.08% (−0.41% 0.15%)
D_ _1500cc	−0.03 Gy (−0.23 Gy, 0.64 Gy)	0.01 Gy (0.00 Gy, 0.09 Gy)	0.03 Gy (−0.13 Gy, 0.74 Gy)
D_ _1000cc	−0.03 Gy (−0.18 Gy, 0.16 Gy)	0.00 Gy (0.00 Gy, 0.02 Gy)	0.03 Gy (−0.09 Gy, 0.46 Gy)

The mean value are cumulative dose differences averaged over all patients. The mean values of the 4D inter-fraction variation are the average values of the largest variations among four fractions over all patients.

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