Table 3 Clinical results of external beam radiation, brachytherapy boost, with or without chemotherapy
Authors (Ref.) | Hishikawa et al.[17] | Flores et al.[23] | Hareyama et al.[18] | Sharma et al.[25] | RTOG9207[16] | Present study* |
|---|---|---|---|---|---|---|
No. of pts. | 148 | 171 | 161 | 100 | 50 | 197 |
BT Gy/fraction | 12/1 | 15/1 | 15-20/NS | 15-20/1 | 15/3 | 12-25/2-6 |
EBRTGy/fraction | 60/30 | 40/15 | 47-70/25-35 | 50/28 | 50 | 30-60 |
CT (pts) | No | No | No | Yes | Yes | 88/197 |
Fistula (%) | 5.3 | 5 | 1.2 | 12 | 12 | 8 (4.1%) |
Bleeding (%) | 0% | 11 | 0 | 4 | NS | 13 (6.6%) |
Ulcer (%) | NS | NS | 3 | 29 | NS | NS |
Stricture (%) | 10 | 35 | 3 | 16 | 4 | 4 (2%) |
Death rate (%) | 3 | 0.6 | 0 | 4 | 8 | 0 |
OS (%) | 37 (2 y) LD | 33 (1 y) | 43.3/Stage I, | 8 (20 Gy) | 49 (1 y) | 57.1 (1 y) |
8 (2 y) ED | 26 (2 y) | 21.1/Stage II, | 23 (15 Gy) | 35.1 (2 y) | ||
19 (3 y) | (5 y) | (5 y) | 9.2 (5 y) | |||
LRC (%) | 64 (2 y) LD | NS | 31.7%(5 y) | NS | 35.9 (5 y) | |