Grade | ||||||
---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 3/4 | ||
Hematological | ||||||
Leukocytopenia | Level 1 (n = 3) | 1 | 0 | 0 | 0 | 0 |
2 (n = 3) | 1 | 0 | 1 | 0 | 1 | |
3 (n = 3) | 1 | 0 | 0 | 0 | 0 | |
Neutropenia | 1 | 0 | 0 | 0 | 0 | 0 |
2 | 0 | 0 | 1 | 0 | 1 | |
3 | 1 | 0 | 0 | 0 | 0 | |
Anemia | 1 | 0 | 0 | 0 | 0 | 0 |
2 | 0 | 0 | 1 | 0 | 1 | |
3 | 0 | 0 | 0 | 0 | 0 | |
Thrombocytopenia | 1 | 1 | 0 | 1 | 0 | 1 |
2 | 2 | 0 | 0 | 0 | 0 | |
3 | 0 | 2 | 0 | 0 | 0 | |
Nonhematological | ||||||
Nausea | 1 | 0 | 1 | 0 | 0 | 0 |
2 | 0 | 0 | 0 | 0 | 0 | |
3 | 1 | 0 | 1* | 0 | 1 | |
Diarrhea | 1 | 0 | 0 | 0 | 0 | 0 |
2 | 0 | 0 | 0 | 0 | 0 | |
3 | 0 | 0 | 1* | 0 | 1 | |
AST/ALT elevation | 1 | 1 | 0 | 0 | 0 | 0 |
2 | 2 | 0 | 0 | 0 | 0 | |
3 | 1 | 0 | 0 | 0 | 0 | |
Bilirubin elevation | 1 | 1 | 1 | 0 | 0 | 0 |
2 | 0 | 1 | 0 | 0 | 0 | |
3 | 1 | 0 | 0 | 0 | 0 | |
Creatinin elevation | 1 | 1 | 0 | 0 | 0 | 0 |
2 | 0 | 0 | 0 | 0 | 0 | |
3 | 1 | 0 | 0 | 0 | 0 |