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Table 3 Logistic regression analysis for grade ≥ 2 RP

From: Pre-radiotherapy FDG PET predicts radiation pneumonitis in lung cancer

Predictor

Coefficient

SE

Odds ratio (95% CI)

p-value

SUVmax

0.16

0.095

1.2 (0.97, 1.4)

0.10

SUVmean

0.34

0.15

1.4 (1.1, 1.9)

<0.02 a,b

SUVSD1

1.5

0.54

4.4 (1.5, 12.8)

<0.0057 a,b

SUV801

0.31

0.13

1.4 (1.1, 1.7)

<0.013 a,b

SUV901

0.33

0.12

1.4 (1.1, 1.7)

<0.0061 a,b

SUV951

0.33

0.12

1.4 (1.1, 1.7)

<0.0049 a,b

HUmax2

0.013

0.02

1 (0.97, 1.1)

0.51

HUmean2

-0.09

0.34

0.91 (0.47, 1.8)

0.79

HUsd2

-0.18

0.93

0.83 (0.14, 5.1)

0.85

HU802

-0.07

0.37

0.93 (0.46, 1.9)

0.85

HU902

-0.10

0.32

0.91 (0.48, 1.7)

0.76

HU952

-0.10

0.32

0.91 (0.48, 1.7)

0.76

MLD3

0.88

0.58

2.4 (0.78, 7.5)

0.13

V53

0.15

0.53

1.2 (0.41, 3.3)

0.77

V103

0.58

0.55

1.8 (0.6, 5.3)

0.30

V203

1.1

0.63

3 (0.87, 10.5)

0.081

V303

1.2

0.57

3.3 (1.1, 10.3)

0.035

FEV1(%)2

-0.13

1

0.88 (0.12, 6.6)

0.897

DLCO(%)2

-1.2

1.1

0.31 (0.034, 2.9)

0.31

  1. 1Scaled by 10.
  2. 2Scaled by 0.01.
  3. 3Log-transformation applied to improve model fit.
  4. aSequentially rejective Bonferroni method applied to adjust for multiplicity at the α = 0.05 familywise significance level.
  5. bOdds of grade ≥ 2 radiation pneumonitis increased with SUVmean, SUVSD, SUV80, SUV90, and SUV95.
  6. Note: SE = standard error of the estimated coefficient parameter; CI = confidence interval for the odds ratio; p-values derived from two-sided hypothesis tests using Wald chi-square.