Involvement of both Cervical Lymph Nodes and Retropharyngeal Lymph Nodes has prognostic value for N1 patients with Nasopharyngeal Carcinoma

Table 4 Univariate analysis of lymph nodes related variables and other clinical factors for 5-year survival

Variable	Patient no.	LFS (%)	p	NFS (%)	p	LRFS (%)	p	DMFS (%)	p	PFS (%)	p	OS (%)	p
Both CLNs and RLNs
Yes	77	77.2	0.068	78.4	0.112	74.6	0.034	72.5	0.004	65.5	0.003	85.3	0.119
No	65	87.1		87.3		87.3		95.2		87.4		95.1
Size of CLNs
CLN ≤ 3 cm	66	81.0	0.988	83.5	0.940	80.5	0.966	79.8	0.426	74.0	0.448	88.8	0.853
CLN 3-6 cm	44	74.1		74.0		72.2		76.0		64.7		87.2
Number of CLNs
Single CLN	62	73.9	0.328	74.1	0.174	70.7	0.154	71.5	0.240	60.3	0.132	85.6	0.562
Multiple CLNs	48	84.8		86.4		84.8		86.7		81.2		90.5
Age
<50	74	83.8	0.858	84.8	0.683	82.4	0.881	81.3	0.649	77.4	0.802	89.9	0.542
>50	68	81.0		81.3		79.8		83.0		74.0		88.9
Sex
Male	106	79.5	0.215	80.6	0.215	78.9	0.355	77.0	0.066	70.6	0.114	86.9	0.123
Female	36	89.3		89.0		86.3		94.3		86.3		97.1
Radiotherapy
2D-RT	35	77.5	0.263	80.5	0.526	75.2	0.207	66.7	0.009	62.4	0.027	83.0	0.160
IMRT	107	83.2		83.0		82.1		89.5		80.5		92.7
Chemotherapy
Yes	16	92.3	0.379	84.6	0.995	84.6	0.815	85.7	0.937	77.9	0.950	92.3	0.765
No	126	80.7		82.4		80.2		81.5		74.4		89.4
Pathology
WHO II	37	76.2	0.238	75.1	0.167	73.0	0.171	79.3	0.347	68.7	0.183	88.1	0.473
WHO III	105	84.3		85.5		83.5		82.6		76.9		90.4
T Stage
T1-T2	85	89.6	0.032	88.5	0.165	87.3	0.097	87.8	0.005	81.6	0.012	94.7	0.048
T3-T4	57	72.5		75.7		72.6		72.5		65.4		82.4

Bold numbers, indicated there was statistically significant difference (p value < 0.05).
RLN indicates retropharyngeal lymph node.
CLN indicates cervical lymph node.
2D-RT indicates Conventional two-dimensional radiotherapy and IMRT indicates Intensity-Modulated Radiation Therapy.
LFS, NFS, LRFS, DMFS, PFS and OS indicate for local recurrence-free survival, nodal recurrence-free survival, local-regional recurrence-free survival, distant metastasis-free survival, progression-free survival and overall survival.

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