MRI and CT imaging for preoperative target volume delineation in breast-conserving therapy

den Hartogh, Mariska D; Philippens, Marielle EP; van Dam, Iris E; Kleynen, Catharina E; Tersteeg, Robbert JHA; Pijnappel, Ruud M; Kotte, Alexis NTJ; Verkooijen, Helena M; van den Bosch, Maurice AAJ; van Vulpen, Marco; van Asselen, Bram; van den Bongard, HJG Desirée

doi:10.1186/1748-717X-9-63

Radiation Oncology

Table 3 Studies reporting the interobserver variability in TB, GTV, CTV and PTV delineation after breast-conserving surgery

From: MRI and CT imaging for preoperative target volume delineation in breast-conserving therapy

		Number of patients	Number of observers	Studied target volume	Volume (cc)¶	Method	Outcome¶
a) CT	Struikmans 2005 [4]	18	5	TB	Mean 20 (6.4-75.8)	CI_pairs	Mean 0.56 (0.39-0.74)
	Petersen 2007 [5]	30	3	TB	Mean 48.7 (10.3-189.3)	CI_common	Mean 0.61 (0.27-0.84)
	Petersen 2007 [5]	30	3	TB	Mean 48.7 (10.3-189.3)	dCOM	0.5-1.1^* (SD 0. 5–1.8)
	Hurkmans 2009 [6]	10	4	TB	40	CI_common	Mean 0.31 (range 0.11 – 0.52)
	Coles 2009 [7]	12	2	TB	29.0 (SD 28.5)	dCOM	Median 3 (range 1–9)
	Coles 2009 [7]	12	2	TB	18.7 (8–116)	dCOM	Median 3 (range 1–9)
	Jolicoeur 2011 [8]	66	3	TB	13.7	CI_common	Mean 0.66
	Giezen 2012 [9]	15	4	TB	27 (SD 25)	CI_gen	0.52 (SD 0.21)
	Giezen 2012 [9]	15	4	TB	27 (SD 25)	dCOM	4 (SD 3)
	Van Mourik 2010 [10]	8	13	CTV	n.a.	CI_pairs	0.61^# (range 0.35 – 0.79)
	Van Mourik 2010 [10]	8	13	CTV	n.a.	dCOM	7.25 (2.73 – 26.87)
	Boersma 2012 [11]	26	5	CTV	41.9 (SD 34)	CI_pairs	0.36 (SD 0.21)
	Boersma 2012 [11]	26	5	CTV	41.9 (SD 34)	dCOM	11 (SD 8)
	Van den Assem 2012 [12]	19	3	CTV	37.6	CI_pairs	Mean 0.59
	Van den Assem 2012 [12]	19	3	CTV	37.6	dCOM	Mean 5.5
	Landis 2007 [13]	29	4	PTV	202 (65–492)	CI_pairs	0.76 (0.52-0.92)
	Landis 2007 [13]	29	4	PTV	202 (65–492)	dCOM	2.5 (0. 7–11.5)
b) MRI	Jolicoeur 2011 [8]	66	3	TB	10.1	CI_common	Mean 0.96
	Giezen 2012 [9]	15	4	TB	27 (SD 26)	CI_gen	0.32 (0.25)
	Giezen 2012 [9]	15	4	TB	27 (SD 26)	dCOM	11(SD 10)
c) CT + additional preop CT	Boersma 2012 [11]	26	5	CTV	36 (SD 31)	CI_pairs	0.36 (SD 0.19)
c) CT + additional preop CT	Boersma 2012 [11]	26	5	CTV	36 (SD 31)	dCOM	10 (SD 7)
	Van den Assem 2012 [12]	19	3	CTV	34.7	CI_pairs	Mean 0.68
	Van den Assem 2012 [12]	19	3	CTV	34.7	dCOM	Mean 2.9
d) Preop CT	Boersma 2012 [11] + vd Leij 2012 [18] (same dataset)	26	5	GTV	0.99	CI_pairs	0.45 (SD 0.22)
				GTV	0.99	dCOM	4.3 (SD 7.6)
				CTV	37.5	CI_pairs	Mean 0.77
				CTV	37.5	dCOM	Mean 4.4
	This study (excluding 2 misdelineations)	12	4	GTV	2.1	CI_pairs	0.56 (0.11 – 0.83)
				GTV	2.1	dCOM	1.1 (0.3 – 12.8)
				CTV	48.1	CIpairs	0.82 (0.39 – 0.93)
				CTV	48.1	CIpairs	1.4 (0.3 – 13.6)
e) Preop MRI	This study (excluding 2 misdelineations)	12	4	GTV	2.7	CI_pairs	0.61 0.37 – 0.78)
				GTV	2.7	dCOM	1.2 (0.3 – 3.6)
				CTV	59.0	CI_pairs	0.84 (0.47 – 0.93)
				CTV	59.0	dCOM	1.8 (0.1 – 4.8)

*Range of the mean dCOM in x-y and z-direction and range in SD.
^#CI values of one observer with all twelve observers were averaged.
^¶Volume, CI and dCOM: reflected in median (range) or mean ± SD, unless stated differently.
TB Tumor Bed volume, GTV Gross Tumor Volume, CTV Clinical Target Volume, PTV Planning Target Volume.
CI Conformity Index, method of analysis (common, pairs, general) as described by Van Kouwenhoven et al. [27].
dCOM Distance between the Centers of Mass (mm).

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ISSN: 1748-717X

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