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Table 3 Studies reporting the interobserver variability in TB, GTV, CTV and PTV delineation after breast-conserving surgery

From: MRI and CT imaging for preoperative target volume delineation in breast-conserving therapy

   Number of patients Number of observers Studied target volume Volume (cc)¶ Method Outcome¶
a) CT Struikmans 2005 [4] 18 5 TB Mean 20 (6.4-75.8) CIpairs Mean 0.56 (0.39-0.74)
  Petersen 2007 [5] 30 3 TB Mean 48.7 (10.3-189.3) CIcommon Mean 0.61 (0.27-0.84)
dCOM 0.5-1.1* (SD 0. 5–1.8)
  Hurkmans 2009 [6] 10 4 TB 40 CIcommon Mean 0.31 (range 0.11 – 0.52)
  Coles 2009 [7] 12 2 TB 29.0 (SD 28.5) dCOM Median 3 (range 1–9)
18.7 (8–116)
  Jolicoeur 2011 [8] 66 3 TB 13.7 CIcommon Mean 0.66
  Giezen 2012 [9] 15 4 TB 27 (SD 25) CIgen 0.52 (SD 0.21)
dCOM 4 (SD 3)
  Van Mourik 2010 [10] 8 13 CTV n.a. CIpairs 0.61# (range 0.35 – 0.79)
dCOM 7.25 (2.73 – 26.87)
  Boersma 2012 [11] 26 5 CTV 41.9 (SD 34) CIpairs 0.36 (SD 0.21)
dCOM 11 (SD 8)
  Van den Assem 2012 [12] 19 3 CTV 37.6 CIpairs Mean 0.59
dCOM Mean 5.5
  Landis 2007 [13] 29 4 PTV 202 (65–492) CIpairs 0.76 (0.52-0.92)
dCOM 2.5 (0. 7–11.5)
b) MRI Jolicoeur 2011 [8] 66 3 TB 10.1 CIcommon Mean 0.96
  Giezen 2012 [9] 15 4 TB 27 (SD 26) CIgen 0.32 (0.25)
dCOM 11(SD 10)
c) CT + additional preop CT Boersma 2012 [11] 26 5 CTV 36 (SD 31) CIpairs 0.36 (SD 0.19)
dCOM 10 (SD 7)
  Van den Assem 2012 [12] 19 3 CTV 34.7 CIpairs Mean 0.68
dCOM Mean 2.9
d) Preop CT Boersma 2012 [11] + vd Leij 2012 [18] (same dataset) 26 5 GTV 0.99 CIpairs 0.45 (SD 0.22)
dCOM 4.3 (SD 7.6)
CTV 37.5 CIpairs Mean 0.77
dCOM Mean 4.4
  This study (excluding 2 misdelineations) 12 4 GTV 2.1 CIpairs 0.56 (0.11 – 0.83)
dCOM 1.1 (0.3 – 12.8)
CTV 48.1 CIpairs 0.82 (0.39 – 0.93)
1.4 (0.3 – 13.6)
e) Preop MRI This study (excluding 2 misdelineations) 12 4 GTV 2.7 CIpairs 0.61 0.37 – 0.78)
dCOM 1.2 (0.3 – 3.6)
CTV 59.0 CIpairs 0.84 (0.47 – 0.93)
dCOM 1.8 (0.1 – 4.8)
  1. *Range of the mean dCOM in x-y and z-direction and range in SD.
  2. #CI values of one observer with all twelve observers were averaged.
  3. Volume, CI and dCOM: reflected in median (range) or mean ± SD, unless stated differently.
  4. TB Tumor Bed volume, GTV Gross Tumor Volume, CTV Clinical Target Volume, PTV Planning Target Volume.
  5. CI Conformity Index, method of analysis (common, pairs, general) as described by Van Kouwenhoven et al. [27].
  6. dCOM Distance between the Centers of Mass (mm).