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Table 3 Studies reporting the interobserver variability in TB, GTV, CTV and PTV delineation after breast-conserving surgery

From: MRI and CT imaging for preoperative target volume delineation in breast-conserving therapy

  

Number of patients

Number of observers

Studied target volume

Volume (cc)¶

Method

Outcome¶

a) CT

Struikmans 2005 [4]

18

5

TB

Mean 20 (6.4-75.8)

CIpairs

Mean 0.56 (0.39-0.74)

 

Petersen 2007 [5]

30

3

TB

Mean 48.7 (10.3-189.3)

CIcommon

Mean 0.61 (0.27-0.84)

dCOM

0.5-1.1* (SD 0. 5–1.8)

 

Hurkmans 2009 [6]

10

4

TB

40

CIcommon

Mean 0.31 (range 0.11 – 0.52)

 

Coles 2009 [7]

12

2

TB

29.0 (SD 28.5)

dCOM

Median 3 (range 1–9)

18.7 (8–116)

 

Jolicoeur 2011 [8]

66

3

TB

13.7

CIcommon

Mean 0.66

 

Giezen 2012 [9]

15

4

TB

27 (SD 25)

CIgen

0.52 (SD 0.21)

dCOM

4 (SD 3)

 

Van Mourik 2010 [10]

8

13

CTV

n.a.

CIpairs

0.61# (range 0.35 – 0.79)

dCOM

7.25 (2.73 – 26.87)

 

Boersma 2012 [11]

26

5

CTV

41.9 (SD 34)

CIpairs

0.36 (SD 0.21)

dCOM

11 (SD 8)

 

Van den Assem 2012 [12]

19

3

CTV

37.6

CIpairs

Mean 0.59

dCOM

Mean 5.5

 

Landis 2007 [13]

29

4

PTV

202 (65–492)

CIpairs

0.76 (0.52-0.92)

dCOM

2.5 (0. 7–11.5)

b) MRI

Jolicoeur 2011 [8]

66

3

TB

10.1

CIcommon

Mean 0.96

 

Giezen 2012 [9]

15

4

TB

27 (SD 26)

CIgen

0.32 (0.25)

dCOM

11(SD 10)

c) CT + additional preop CT

Boersma 2012 [11]

26

5

CTV

36 (SD 31)

CIpairs

0.36 (SD 0.19)

dCOM

10 (SD 7)

 

Van den Assem 2012 [12]

19

3

CTV

34.7

CIpairs

Mean 0.68

dCOM

Mean 2.9

d) Preop CT

Boersma 2012 [11] + vd Leij 2012 [18] (same dataset)

26

5

GTV

0.99

CIpairs

0.45 (SD 0.22)

dCOM

4.3 (SD 7.6)

CTV

37.5

CIpairs

Mean 0.77

dCOM

Mean 4.4

 

This study (excluding 2 misdelineations)

12

4

GTV

2.1

CIpairs

0.56 (0.11 – 0.83)

dCOM

1.1 (0.3 – 12.8)

CTV

48.1

CIpairs

0.82 (0.39 – 0.93)

1.4 (0.3 – 13.6)

e) Preop MRI

This study (excluding 2 misdelineations)

12

4

GTV

2.7

CIpairs

0.61 0.37 – 0.78)

dCOM

1.2 (0.3 – 3.6)

CTV

59.0

CIpairs

0.84 (0.47 – 0.93)

dCOM

1.8 (0.1 – 4.8)

  1. *Range of the mean dCOM in x-y and z-direction and range in SD.
  2. #CI values of one observer with all twelve observers were averaged.
  3. Volume, CI and dCOM: reflected in median (range) or mean ± SD, unless stated differently.
  4. TB Tumor Bed volume, GTV Gross Tumor Volume, CTV Clinical Target Volume, PTV Planning Target Volume.
  5. CI Conformity Index, method of analysis (common, pairs, general) as described by Van Kouwenhoven et al. [27].
  6. dCOM Distance between the Centers of Mass (mm).