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Table 2 Test of the applied second cancer model by comparison of modeled and observed relative breast cancer risk

From: Radiation-induced second malignancies after involved-node radiotherapy with deep-inspiration breath-hold technique for early stage Hodgkin Lymphoma: a dosimetric study

Planning paradigm

Used treament plans

Weighting according to # treated patients

Calculated relative risk (this work)

Observed relative risk from De Bruin et al. [[24]]

Mediastinal

Mediastinal

109

1

1

Mantle

Mantle field alone

637

2.2

2.7 (1.1-6.9)

Other Supradiaphragmatic

Supraclavicular/neck

34

  
 

Axillary + Mediastinal/homolat

41

  
 

Axillary + Mediastinal/bilat

7

  
 

Axillary, no Media.

14

  
 

Total

96

1.0

0.9 (0.2-4.8)

  1. Modeling was performed with a total dose of 40 Gy delivered in 2 Gy fractions.