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Figure 3 | Radiation Oncology

Figure 3

From: Establishment of a small animal tumour model for in vivo studies with low energy laser accelerated particles

Figure 3

Characterization of the tumour micromilieu at starting size. Representative pictures of KHT mouse sarcoma characterized at start of treatment with a size of 2 mm in diameter: (a) The limited and bordered tumour volume was confirmed by standard H&E staining, showing (b + c) the integrity of cellular components by differentiating the basophil stained nuclei from the eosinophil stained cytoplasm, whereas necrosis of single cells cannot be excluded (Figures b and c are higher magnifications of Figure a). (d) The analysis of the tumour histology revealed a well perfused tumour (blue, Hoechst 33342) that is interspersed with small vessels (red, CD31) and some hypoxic area (green, pimonidazole).

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