Figure 1

Mouse positioning at the two radiation sources. Mouse setup boxes for mouse fixation and reproducible tumour positioning at the 200 kV X-ray tubes (a) and at the JETI laser accelerator (b). The mice were placed dorsoventral in the mouse setup boxes gently fixing the right ears on the PMMA block right outside of the box. (a) For irradiation at the vertical 200 kV X-ray beam the boxes were placed at defined positions under the collimator (not shown) allowing tumour irradiation under protection of the animal. (b) The horizontal electron beam delivery at JETI requires the tilt of the setup box so, that the right ear points downwards into the irradiation field. Moreover, cooling of the animals was avoided by heating up the setup boxes at JETI[15].