Figure 4

Effects of ATM-ATR inhibitors on the transcriptions of NKG2D ligands in lung cancer cells. A549 cells were unaffected by KU-55933 or caffeine (A), though caffeine marginally suppressed MICA transcription. Radiation or radiation plus ATM-ATR inhibitors did not affect NKG2D ligand transcription in A549 cells (B). The induced transcription of NKG2D ligands by HDAC inhibitors was not blocked by ATM-ATR inhibitors in A549 or NCI-H23 cells (C).