Table 4 Re-irradiation for cerebral metastases: overview of publications
Shehata et al.[10] | Kurup et al.[11] | Hazuka and Kinzie[12] | Cooper et al.[13] | Wong et al.[14] | Abdel-Wahab et al.[15] | Sadikov et al.[16] | Son et al.[9] | Present study | |
|---|---|---|---|---|---|---|---|---|---|
n | 35 | 56 | 44 | 52 | 86 | 15 | 72 | 17 | 134 |
Initial RT | 1×10 Gy, | 3×6 Gy | 10×3 Gy | 10×3 Gy | 10×3 Gy | 15×2 Gy | 5×4 Gy | 14×2.5 Gy | 15×2 Gy |
10×3 Gy | |||||||||
Re-RT | 1×10 Gy | 10×2 Gy | 8×3.125 Gy | 10×2.5 Gy | 10×2 Gy | 20×1.5 Gy twice daily (partial brain) | 10×2.5 Gy | 12×1.8 Gy | 10×2 Gy |
Interval | - | 6.3 mo (mean) | 7.8 mo (median) | > 4 mo | 7.6 mo (median) | 10 mo (median) | 9.6 mo (median) | 15 mo (median) | 13.4 mo (median) |
Response | |||||||||
Improve | 68% | 75% | 27% | 42% | 70% | 60% | 40% | 80% | 39% |
Stable | 25% | 12.5% | 41% | 52% | 29% | 27% | 33% | 20% stable or no response | 44% |
None | 12.5% | 14% | 6% | 33% | 17% | ||||
Toxicity | 17% acute side effects | 18% acute side effects 1 radiation necrosis | 8 autopsies, 3 brain necroses | - | 5 patients with radiographic abnormality | 1 patient with severe side effects 3 unable to complete RT | 71% with acute side effects | 67% with acute side effects 10% unable to complete RT | |
Survival after re-irradiation | - | 3.5 mo median | 2 mo median | 4 mo median | 4 mo median | 3.2 mo median | 4.1 mo median | 5.2 mo median | 2.8 mo median |