Table 2 Multivariable analysis

Primary tumor

SCLC

0.019

0.59 (0.38 – 0.92)

Extracerebral control

No control of primary

<0.001

2.32 (1.47 – 3.66)

Karnofsky performance status

KPS <70

0.038

n/a**

Higher RPA class

RPA 3

n/a*

n/a**

Symptoms

Severe symptoms

0.070

n/a**

Interval between WBRT 1 and 2

0.557

1.12 (0.76 – 1.65)

Dose for re-irradiation

0.586

1.18 (0.65 – 2.16)

Male gender

0.087

1.45 (0.95 – 2.22)

Age ≥ 60

0.773

1.07 (0.69 – 1.65)