Skip to main content

Table 5 Clinical predictors of vaginal ulcer

From: Vaginal tolerance of CT based image-guided high-dose rate interstitial brachytherapy for gynecological malignancies

Characteristic

Vaginal ulcer (+) (n = 5)

Vaginal ulcer (-) (n = 39)

p value

Prior pelvic RT*

3

5

0.035*

Yes

2

34

No

  

Concurrent chemotherapy

  

0.256

Yes

0

10

No

5

29

Median number of needles used in HDR-ISBT (range)

14 (10-24)

15 (5-29)

0.293

Median CTV (ml, range)

54.7 (17.7-114.0)

34.7 (2.4-142.1)

0.271

Median rectum D2cc†† (EQD2||, Gy, range)

84.2 (34.0-100.7)

57.9 (30.5-114.3)

0.118

Median bladder D2cc†† (EQD2||, Gy, range)

69.3 (37.4-113.5)

57.7 (7.3-120.3)

0.091

Median vaginal wall D0.5cc†† (EQD2||, Gy, range)

206.4 (106.6-349.3)

149.4 (47.9-310.1)

0.243

Median vaginal wall D1cc†† (EQD2||, Gy, range)

169.1 (91.6-277.5)

127.9 (33.6-220.8)

0.096

Median vaginal wall D2cc†† (EQD2||, Gy, range)

152.5 (71.1-247.5)

109.0 (31.7-201.9)

0.025*

Median vaginal wall D4cc†† (EQD2||, Gy, range)

115.5 (83.8-200.8)

110.6 (34.0-153.2)

0.152

Median vaginal wall D6cc†† (EQD2||, Gy, range)

102.5 (60.4-173.7)

99.5 (20.4-146.3)

0.266

Median vaginal wall D8cc†† (EQD2||, Gy, range)

82.0 (47.6-144.4)

84.3 (10.3-140.3)

0.511

  1. *RT: radiation therapy.
  2. HDR-ISBT.
  3. CTV: clinical target volume.
  4. ||EQD2: equivalent dose in 2 Gy fractions.
  5. ††D0.5cc, D1cc, D2cc, D4cc, D6cc, D8cc: most exposed 0.5, 1, 2, 4, 6, and 8 cm3 of tissue.