Figure 7

Mice implanted with EGFR-luc transfected H322 tumors over the right flank. EGFR activation during radiotherapy (B, C; 3x6Gy) induces consecutive Luciferase expression and thus detectable bioluminescence upon luciferine injection. Mice implanted into the right flank with EGFR-luc transfected H322 tumors. EGFR activation during radiotherapy (B, C; 3x6Gy) induces consecutive Luciferase expression and thus detectable Bioluminescence upon Luciferine injection. Changes to the EGFR activation by EGFR inhibition with e.g. Gefitinib (C) result in detectable alterations of the signal. Non-treated tumors (A) do not exhibit a specific signal. Adapted by permission from the American Association for Cancer Research: Li et al., Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo. Cancer Research, 2008, 68, 4990–7. [109].