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Table 3 Survival time of rats bearing F98 gliomas following CED of carboplatin (10 μg × 2) and 15 Gy X-irradiation (7.5 Gy × 2)

From: Radiation therapy combined with intracerebral administration of carboplatin for the treatment of brain tumors

 

Survival times (days)c

% Increased life span

Treatment groupa

N

Mean ± SE

Median

Range

Mean

Median

Untreated

5

24.6 ± 1.1

25

21–28

0

0

X-irradiationb

4

30.0 ± 1.9

30

28–32

22

20

CED of carboplatin

5

46.8 ± 7.5

43

33–67

90

72

CED of carboplatin + X-ray

12

82.1 ± 15.5

54.5

35 > 180(3)

234

118

  1. aStereotactic intracerebral implantation of 103 F98 glioma cells was carried out on d. 0. Carboplatin (10 μg in 10 μL) was administered by convection enhanced delivery at a flow rate of 0.33 μL/min. for 30 min on day 13th and 15th.
  2. bAnimals received 15 Gy of 6 MV LINAC X-rays, delivered in two 7.5 Gy fractions on day 14th and 16th.
  3. cSurvival of >180 d. indicates that these animals have been cured of their tumors. The number in parenthesis indicates the number of long-term survivors.
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Radiation Oncology

ISSN: 1748-717X

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