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Table 2 Survival data of F98 rats following CED of carboplatin in combination with X-irradiation

From: Radiation therapy combined with intracerebral administration of carboplatin for the treatment of brain tumors

 

Survival times (days)b

% Increased life span

Treatment groupa

N

Mean ± SE

Median

Range

Mean

Median

Untreated controls

5

24.6 ±1.1

25

21–28

0

0

X-irradiation

5

35.3 ±1.8

35.5

31–39

43

42

CED of carboplatin (on day 13) + X-irradiation (6 h later)

8c

80.6 ±18.5c

48

27- > 180(2)

227

92

CED of carboplatin (on day 13) + X-irradiation

8

83.6 ±21.5

55.5

39- > 180(2)

240

122

CED of carboplatin (on day 7) + X-irradiation

8d

72.1 ±17.3d

49

9- > 180(2)

193

96

Alzet pump deliverye (d 7-13) + X-irradiation

8

107.7 ±21

62

42- > 180(3)

337

148

  1. aStereotactic intracerebral implantation of 103 F98 glioma cells was carried out on d 0. Carboplatin (20 μg in 10 μL) was administered by convectionenhanced delivery at a flow rate of 0.33 μL/min. for 30 min. on d 13 following implantation. Alternatively, they received 84 μg of the drug by Alzet pumps over 7 d (168 μl at 1 μl/h). Animals received 20 Gy of 6 MV LINAC X-rays, delivered in 5 Gy fractions beginning 24 hrs after CED unless otherwise indicated.
  2. bN indicates the number of animals per group and SE designates the standard error. Survival of >180 d indicates that these animals have been cured of their tumors. The number in parenthesis indicates the number of long-term survivors.
  3. cThree treatment-related early deaths on d 27 and 29 were included in these calculations.
  4. dTwo treatment-related early deaths on d 9 and 10 were included in these calculations.
  5. eCarboplatin was administered by Alzet pump (84 μg over 168 hr) followed 24 hr later by X-irradiation.