Figure 1

Kaplan-Meier survival plots of F98 glioma bearing rats following administration of carboplatin by CED or Alzet pumps in combination with X-irradiation. Survival times in days after implantation have been plotted for untreated animals (●), X-irradiation only (5 Gy × 4) (○), CED of carboplatin (20 μg) + X-irradiation 6 h later (▼), CED of carboplatin (20 μg) at 7 d + X-irradiation (Δ), CED of carboplatin (20 μg) + X-irradiation 24 h later (■), carboplatin (84 μg) administered by Alzet pumps + X-irradiation (□), and CED of carboplatin (10 μg × 2) on days 13 and 15 + X-irradiation (7.5 Gy × 2) on days 14 and 16 (♦).