Study | Design | N patients | EBRT technique | EBRT dosage (Gy) | Taxane drug | Taxane dosage (mg/m2) | ADT duration (months) | Toxicity scoring system | Highest acute GU toxicity § | Highest acute GI toxicity § | Highest late toxicity § | Biochemical recurrence | Follow-up, median (months) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Kumar [14] | Phase I | 22 | 3D-CRT | 70.2 | Docetaxel | 5 (n=3), 8 (n=3), | None | CTC v2.0, RTOG † | Grade 2 | Grade 3 | Urinary | 5/8 | 8 |
12 (n=3), 16 (n=5), | Frequency/urgency | Diarrhea (n=2) | Retention (n=1) | ||||||||||
20 (n=6), 25(n=2) | (n=8) | ||||||||||||
Sanfilippo [23] | Phase I/II | 22 | 3D-CRT | 63 (n=3), 66.6 | Paclitaxel | 30 | 9 | CTC v2.0 | Grade 2 | Grade 3 | Grade 1 | 6/22 | 38 |
(n=7), 70.2 (n=4), | Frequency/urgency | Diarrhea (n=4) | Frequency | ||||||||||
73.8 (n=8) | (n=4) | (n=2) | |||||||||||
Perrotti [15] | Phase I/II | 20 | IMRT | 72 | Docetaxel | 20 | None | CTC, | Grade 2 | Grade 2 | none | 3/20 | 11.7 |
RTOG † | Frequency (n=7) | Diarrhea (n=8) | |||||||||||
Bolla [16] | Phase II | 50 | 3D-CRT (n=45), | 70 | Docetaxel | 20 | <36 (n=6), | CTC v2.0, | Grade 3 | Grade 4 | Grade 3 | NR ‡ | 54 |
IMRT (n=5) | 36 (n=43), | RTOG † | Dysuria (n=2) | Proctitis (n=1) | Proctitis (n=1) | ||||||||
>36 (n=1) | |||||||||||||
Hussain [24] | Phase I | 59 | 3D-CRT | 70.2 (n=29), | Paclitaxel | 40 (n=10), | 4 (n=29), | CTC v2.0 | Grade 2 | Grade 3 | NA | 13/29, 11/30* | 76.3, 74.9* |
64.8 (n=30)* | 50 (n=31), | 24 (n=30) | Frequency/urgency/ | Diarrhea (n=9) | |||||||||
60 (n=18) | Incontinence (n=5) | ||||||||||||
Chen [25] | Phase I | 18 | IMRT | 78 | Docetaxel | 10 (n=9), | 24 | CTCAE v3.0 | Grade 2 | Grade 3 | NA | 3/18 | 26 |
15 (n=6), | Frequency (n=2) | Diarrhea (n=2) | |||||||||||
20 (n=3) | |||||||||||||
Present series | Phase II | 35 | IMRT | 80 (n=17), | Docetaxel | 30 mg (n=8), | 24 | CTCAE v3.0 | Grade 3 | Grade 3 | Grade 2 urinary | 6/17, 8/18* | 63 |
70 (n=18)* | 40 mg (n=27) | Urinary retention | Diarrhea | Retention | |||||||||
(n=1) | (n=2) | (n=2) |