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Table 3 Factors associated with actuarial risk of developing BM for patients with resectable SCLC

From: Risk factors for brain metastases in completely resected small cell lung cancer: a retrospective study to identify patients most likely to benefit from prophylactic cranial irradiation

Factors

Univariate analysis

Multivariate analysis

1y

3y

3y

p

HR

95% CI

p

Gender

       

Male

14.3

23.0

     

Female

12.0

23.6

0.04

0.906

   

Age, years

       

<65

14.5

22.4

     

≥65

12.0

26.3

0.063

0.802

   

KPS score

       

≥80

10.6

17.3

     

<80

16.0

31.5

1.207

0.272

   

Smoking status

       

Positive

15.9

24.7

     

Negative

11.2

20.9

0.341

0.559

   

P-stage

       

I

3.1

9.7

     

II

15.4

18.5

     

III

18.8

35.4

8.621

0.013

2.013

1.135 ~ 3.569

0.017

LVI

       

Yes

30.8

39.9

     

No

9.8

17.5

8.943

0.003

1.924

1.002 ~ 3.291

0.039

PORT

       

Yes

17.6

33.5

     

No

13.2

21.3

3.351

0.067

0.825

0.329 ~ 2.064

0.680

Cycle of ChT

       

<4

10.0

17.5

     

≥4

14.5

24.2

0.240

0.624

   
  1. Abbreviations: SCLC = small cell lung cancer; 1y = actuarial risk of developing BM at 1 year; 3y = actuarial risk of developing BM at 3 years; HR = hazard ratio; CI = confidence interval; KPS = Karnofsky performance status; P-stage = pathologic stage; LVI = lymphovascular invasion; PORT = postoperative radiotherapy; ChT = chemotherapy.
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Radiation Oncology

ISSN: 1748-717X

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