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Table 3 Factors associated with actuarial risk of developing BM for patients with resectable SCLC

From: Risk factors for brain metastases in completely resected small cell lung cancer: a retrospective study to identify patients most likely to benefit from prophylactic cranial irradiation

Factors Univariate analysis Multivariate analysis
1y 3y 3y p HR 95% CI p
Gender        
Male 14.3 23.0      
Female 12.0 23.6 0.04 0.906    
Age, years        
<65 14.5 22.4      
≥65 12.0 26.3 0.063 0.802    
KPS score        
≥80 10.6 17.3      
<80 16.0 31.5 1.207 0.272    
Smoking status        
Positive 15.9 24.7      
Negative 11.2 20.9 0.341 0.559    
P-stage        
I 3.1 9.7      
II 15.4 18.5      
III 18.8 35.4 8.621 0.013 2.013 1.135 ~ 3.569 0.017
LVI        
Yes 30.8 39.9      
No 9.8 17.5 8.943 0.003 1.924 1.002 ~ 3.291 0.039
PORT        
Yes 17.6 33.5      
No 13.2 21.3 3.351 0.067 0.825 0.329 ~ 2.064 0.680
Cycle of ChT        
<4 10.0 17.5      
≥4 14.5 24.2 0.240 0.624    
  1. Abbreviations: SCLC = small cell lung cancer; 1y = actuarial risk of developing BM at 1 year; 3y = actuarial risk of developing BM at 3 years; HR = hazard ratio; CI = confidence interval; KPS = Karnofsky performance status; P-stage = pathologic stage; LVI = lymphovascular invasion; PORT = postoperative radiotherapy; ChT = chemotherapy.