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Table 2 Univariate and multivariate analysis of the effect of prognostic factors on OS in patients with resectable SCLC

From: Risk factors for brain metastases in completely resected small cell lung cancer: a retrospective study to identify patients most likely to benefit from prophylactic cranial irradiation

Factors Univariate analysis Multivariate analysis
2y-OS % 5y-OS % X 2 p HR 95% CI p
Gender        
Male 63.0 48.4      
Female 64.0 43.6 0.015 0.901    
Age, years        
<65 64.8 53.3      
≥65 58.9 32.2 3.079 0.079 1.798 1.027 ~ 3.148 0.040
KPS score        
≥80 71.5 56.9      
<80 61.5 42.3 3.487 0.062 1.149 0.631 ~ 2.092 0.649
Smoking status        
Yes 62.1 52.0      
No 64.7 42.3 0.284 0.594    
P-stage        
I 87.1 74.4      
II 78.6 61.7      
III 42.6 26.6 28.70 0.001 2.093 1.399 ~ 3.132 0.001
LVI        
Yes 48.6 34.1      
No 67.6 51.8 3.358 0.067 0.935 0.507 ~ 1.723 0.829
PORT        
Yes 64.7 43.6      
No 63.0 48.2 0.028 0.866    
Cycle of ChT        
<4 61.9 57.1      
≥4 63.5 46.0 0.221 0.638    
Brain metastasis        
Yes 42.9 15.5      
No 69.0 56.2 14.65 0.001 2.092 1.049 ~ 4.170 0.031
  1. Abbreviations: OS = overall survival; SCLC = small cell lung cancer; 2y-OS = overall survival rate at 2 years; 5y-OS = overall survival rate at 5 years; HR = hazard ratio; CI = confidence interval KPS = Karnofsky performance status; P-stage = pathologic stage; LVI = lymphovascular invasion; PORT = postoperative radiotherapy; ChT = chemotherapy.