Figure 2

Reactome FI functional interaction network generated using the differentially expressed genes from a study by Henriquez et al. [[33]] comparing global microarray expression profiles of lymphocytes from patients before and after 2Gy X-ray irradiation. From the 66 HGNC annotated genes (Supplementary table two [33]) 44 were found to be part of an interaction network. So-called linkers (n=15) i.e. proteins not part of the gene list that allow indirect interaction between two genes are indicated by diamond-shape nodes and the genes from the list by circles. Predicted interactions are indicated by dashed black lines and interactions for which experimental evidence exists by solid black lines. Where known the type of interaction is indicated by arrow-headed lines (activating) or by bar-headed lines (inactivating/inhibiting).