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Figure 5 | Radiation Oncology

Figure 5

From: RAD9 deficiency enhances radiation induced bystander DNA damage and transcriptomal response

Figure 5

Network analysis and comparison of regulation in H1299 shRAD9 bystander response. A and B. Volcano plots showing significantly responding genes (blue) above the p value cut-off -log10 (0.006) shown as the bold dashed line in directly irradiated cells corresponding to bystander positive (DBP) and bystander positive (BP) H1299shRAD9 cells, respectively. Values are log2 (fold change) on the x-axis and -log10 (p value) on the y-axis. C. and D. Ingenuity Pathways analysis (IPA) generated SP1 network, overlaid with relative gene expression in directly irradiated (DBP) and corresponding bystander positive (BP) cells, respectively. E. Ingenuity Pathways analysis (IPA) generated NUPR1 networks, overlaid with relative gene expression in directly irradiated cells corresponding to bystander positive (DBP). F. IPA generated NUPR1 network in bystander positive (BP) cells. In all network diagrams, up regulated genes are colored red and down regulated genes green, with fold changes shown under the nodes. Blank nodes are genes that are in the network but not in the dataset. Solid edges (lines and arrows between nodes) represent direct interactions between molecules and dashed edges represent indirect associations between molecules based on information in the Ingenuity knowledge base. Orange colored lines and nodes represent known activation and blue colored lines and nodes represent known inhibition. A grey line represents an unchanged or unpredicted relationship between two nodes. Numbers under nodes are fold-change values.

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