The prognostic role of EZH2 expression in rectal cancer patients treated with neoadjuvant chemoradiotherapy

Radiation Oncology

Table 2 Correlations between clinicopathological parameters and tumor response

Parameters	Cases N = 112	Tumor regression grade		p value	Tumor		p value
Parameters	Cases N = 112	Good response	Poor response	p value	Down-staging	Non-down-staging	p value
Age
<62	49	24	25	0.519	26	23	0.943
≥62	63	27	36		33	30
Sex
Male	71	34	37	0.511	41	30	0.157
Female	41	17	24		18	23
Distance from anal verge (cm)
<6	39	18	21	0.924	23	16	0.329
≥6	73	33	40		36	37
Histology
Differentiated	64	28	36	0.661	31	33	0.299
Undifferentiated	48	23	25		28	20
CEA(ng/ml)
<3.4	52	30	22	0.016	33	19	0.033
≥3.4	60	21	39		26	34
Clinical Tumor status
cT3	62	35	27	0.01	37	25	0.099
cT4	50	16	34		22	28
Clinical Node status
cN0	38	23	15	0.022	25	13	0.046
cN+	74	28	46		34	40
EZH2
Low	53	30	23	0.026	34	19	0.021
High	59	21	38		25	34

ISSN: 1748-717X