From: mRNA-based vaccines synergize with radiation therapy to eradicate established tumors
Pathway/function | Genes upregulated upon tumor radiation |
---|---|
T cell signaling | Cd8b1 (2.8), Cd8a (2.6), Il12r (2.2), Il2r (2.1), Gzmb (3.8), Gzmk (1.9), Prf1 (2.2), Icos (2.4), Ctla4 (1.4), Eomes (1.6), Stat1 (1.6), Stat4 (2.4) |
NK cell signaling | Klrd1 (3.1), Klrk1 (2.1), Klrc1 (3.0), Klra2 (1.6), Nkg7 (4.0), Il12r (2.2), Gzmb (3.8), Gzmk (1.9), Prf1 (2.2), Fcgr4 (2.2) |
Chemotaxis | Ccl3 (2.0), Ccl5 (2.5), Ccl8 (2.1), Ccl11 (2.2), Cxcl12 (1.6), Cxcl16 (2.1), Ccrl2 (2.1), Ccr5 (1.7), Cxcr3 (1.5) |
TLR signaling | Tlr7 (1.9), Tlr8 (2.2), Tlr9 (1.6), Tlr13 (1.7), Irak3 (1.5), Aebp1 (2.5) |
MHC class II presentation | H2-Dma (1.8), H2-Ab1 (1.7), H2-Eb1 (1.5), H2-Aa (1.9), H2-T24 (1.8), Cd74 (1.7), Cathepsins: k, s, c, h, w, a (1.6-2.0), Anpep (1.9) |
Complement system | C1qa (2.0), C1qb (1.6), C1qc (2.1), C1r (1.7), C2 (2.2), C3 (2.0), C4b (2.6), Cfb (2.1), Cfh (1.9) |
Dendritic cells, macrophages | Cd11c (Itgax) (1.9), Cd11b (Itgam) (1.7), Clec4a1 (2.1), Clec4a3 (2.2), Ly6i (2.3), Sema4 (1.9), Blnk (1.6), Lrp1 (2.6), Aebp1 (2.5), Nos2 (2.4) |
Adhesion | Vcam1 (1.8), Lamc1 (1.8), Tns1 (1.8), Cd38 (1.8), Itgam (1.7), Itgax (1.9), Thbs1 (1.5), Thbs2 (2.2), Clec4a1 (2.1), Clec4a3 (2.2), Antxr (2.6) |
Angiogenesis | Ecm1 (2.1), Ptafr (1.6), Hpse (2.1), Atxr1 (2.6), Fgfr1 (1.6), Mmp13 (4.1), Mmp19 (1.7), Thbs1 (1.5), Nrp2 (1.8), Nrp1 (2.4), Crim1 (1.5), Ace (2.1), Plxdc2 (1.8) |